198 documents found, page 1 of 20
Experimental investigation of cellular steel beams at ambient and elevated temp...
Silva, Luana Vidoti da; Giacomitti, Nickolas; Ferreira, Débora; Lopes, Nuno; Mesquita, Luís M.R.Cellular steel beams, commonly used in modern construction, exhibit complex failure mechanisms that have not been thoroughly explored, especially under fire conditions. This research investigates the structural behaviour of cellular beams under both ambient and elevated temperatures, with a focus on load-bearing capacity and failure modes. Experimental tests were conducted on a solid beam and six cellular beams...
Os maus tratos contra crianças no contexto familiar
Ferreira, DéboraO presente Relatório de Estágio, intitulado “Os Maus Tratos Contra Crianças no Contexto Familiar: o retrato de um CAFAP na Área Metropolitana do Porto” foi realizado no âmbito do Mestrado em Intervenção Social na Infância e Juventude em Risco de Exclusão Social, tendo como objetivo analisar e compreender a presença e dimensão da problemática dos maus tratos no contexto de um Centro de Apoio Familiar e Aconselha...
Influence of puncture devices on the accuracy of cyclophosphamide dosing for ch...
Carvalho, Susana; Cardoso, Andreia; Ferreira, Débora; Silva, Diana Dias da; Moreira, Fernando; Moreira, Fernando; Dias da Silva, Diana CristinaCyclophosphamide is one of the most commonly used cytotoxic drugs in chemotherapy protocols. Its preparation in the hospital setting involves handling concentrated solutions, which pose occupational exposure risks and potential variations in the final dose administered. The aim of this study was to evaluate the effect of aspiration devices on the concentration of cyclophosphamide in reconstituted solutions. An ...
RNA-based therapeutics: cutting-edge advances in clinical research
Ferreira, Débora; Rodrigues, L. R.Over the years, the relevance of gene therapy has increased as an alternative to conventional drugs. Pharmaceutical industries have been directing their efforts toward the creation of novel gene-based therapies for a broad range of diseases. RNA-based therapeutics can efficiently trigger gene silencing and, despite the initial research setbacks, this technology laid the groundwork for advancements in RNA-based ...
Molecular docking reveals CDK1 as a therapeutic target of novel purine derivati...
Pereira, Ana; Fernandes, Soraia P.; Leite, Bruna; Vieira, Rafael; Pereira, Cátia S.; Ferreira, Débora; Sousa, Sérgio F.; Dias, Alice M.Triple negative breast cancer (TNBC) accounts for about 15% of the more than two million breast cancer cases diagnosed annually. Defined by the lack of estrogen (ER), progesterone (PR), and epidermal growth factor receptor 2 (HER2) expression, TNBC is highly aggressive, exhibits rapid proliferation, and shows poor response to conventional and hormonal therapies, highlighting the urgent need for new therapeutic ...
Targeting miR-155 in triple negative breast cancer via CRISPR/Cas9 delivery usi...
Ferreira, Débora; Sousa, Diana Andrade; Da Silva, Catarina; Gandarela, Leonor B.; Sousa, Mariana Martins; Rodrigues, L. R.Triple negative breast cancer (TNBC) represents a heterogeneous and aggressive subtype of breast cancer, accounting for 10-20% of all cases. It is associated with a poor prognosis due to the absence of effective targetable biomarkers and high metastatic potential. Despite advances in cancer therapy, TNBC remains a challenging condition for clinicians, highlighting the need for novel therapies. Dysregulation of ...
Smart extracellular vesicles for targeted therapy in breast cancer
Ferreira, Débora; Gandarela, Leonor B.; Silva, Catarina; C. Novo, Inês; Sousa, Mariana Martins; Pereira, Ana; Sousa, Diana Andrade; Rodrigues, L. R.A central challenge in cancer nanomedicine is achieving selective drug delivery that directs therapeutic agents specifically to tumor cells while minimizing adverse effects on healthy tissues. Over the past decades, drug delivery systems have advanced considerably, with nanocarriers explored as promising vehicles to improve treatment outcomes. Among these, extracellular vesicles (EVs), which are lipid bilayer e...
AptaVerse - Unveiling the full potential of aptamers in oncology
Ferreira, Débora; Rodrigues, L. R.Cancer continues to pose a major global health burden, largely due to its complexity and heterogeneity, which limit the effectiveness of conventional therapies. Developing new strategies that selectively target malignant cells while sparing healthy tissues remains an urgent priority. An emerging approach in tumor-targeted therapies involves the use of aptamers, short single-stranded oligonucleotides capable of ...
Harnessing lactoferrin-loaded extracellular vesicles for colorectal cancer trea...
Novo, Inês C.; Pereira, Cátia S.; Rodrigues, L. R.; Ferreira, DéboraColorectal cancer (CRC) is characterized by the uncontrolled proliferation of abnormal cells in the lining of colon and rectum. Primary treatment modalities for CRC, including surgical intervention and chemotherapy, often fail to provide long-term outcomes. Therefore, there is an urgent need for innovative, targeted therapies to enhance patient prognosis and survival rates. Bovine lactoferrin (bLf), a natural m...
Aptamer-based therapy for fighting biofilm-associated infections
Sousa, Ana Margarida; Ferreira, Débora; Rodrigues, L. R.; Pereira, Maria OlíviaBiofilms are key players in the pathogenesis of most of chronic infections associated with host tissue or fluids and indwelling medical devices. These chronic infections are hard to be treated due to the increased biofilms tolerance towards antibiotics in comparison to planktonic (or free living) cells. Despite the advanced understanding of their formation and physiology, biofilms continue to be a challenge and...