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Lactoferrin-loaded magnetic liposomes as potential photothermal agents for brea...

Andrade, Raquel G. D.; Santos-Pereira, Cátia; Ferreira, Débora Carina Gonçalves Abreu; Castanheira, Elisabete M. S.; Rodrigues, L. R.

Nanoparticle-based drug delivery systems can afford an alternative treatment for breast cancer, overcoming conventional therapy’s limitations. In particular, superparamagnetic iron oxide nanoparticles entrapped in liposomes have gained significant interest in the biomedical field due to their exceptional properties, like enabling their accumulation at the intended target site when exposed to an external magneti...


Citrate-coated manganese and calcium ferrite nanoparticles as potential magneti...

Andrade, Raquel G. D.; Ferreira, Débora Carina Gonçalves Abreu; Veloso, Sérgio Rafael Silva; Santos-Pereira, Cátia; Castanheira, Elisabete M. S.

IX Workshop de Bioquímica Clínica (IX-CBW) [formato misto] Campus de Gambelas, Universidade do Algarve, dia 26 de janeiro 2024.; In this work, manganese/calcium ferrite NPs coated with citrate, were synthesized by the sol-gel method, followed by calcination, and then characterized regarding their crystalline structure (by X-ray diffraction, XRD), size and shape (by Transmission Electron Microscopy, TEM), hydrod...


Nanoformulações de um novo composto muito promissor para terapia do cancro da m...

Teixeira, Marta Sofia Vilela Barreira; Ferreira, Débora Carina Gonçalves Abreu; Rodrigues, L. R.; Castanheira, Elisabete M. S.; Carvalho, M. Alice

No presente estudo pretendeu-se desenvolver, caracterizar e avaliar o efeito antitumoral de nanoformulações carregadas com o composto Hit. As formulações carregadas com o composto hit foram caracterizadas por DLS (tamanho hidrodinâmico, índice de polidispersividade e potencial zeta), e a cinética de libertação do composto. Adicionalmente, os efeitos antitumorais das nanoformulações foram determinados na linha c...


Design of new hydrolyzed collagen-modified magnetic nanoparticles to capture pa...

Sande, Maria Georgina; Roque, Lúcia; Braga, Adelaide Correia; Marques, Márcia; Ferreira, Débora Carina Gonçalves Abreu; Saragliadis, Athanasios

Enrichment and diagnosis tools for pathogens currently available are time consuming, thus the development of fast and highly sensitive alternatives is desirable. In this study, a novel approach was described that enables selective capture of bacteria expressing hydrolyzed collagen-binding adhesins with hydrolyzed collagen-coated magnetic nanoparticles (MNPs). This platform could be useful to shorten the time ne...


Exosomes modified with anti-MEK1 siRNA lead to an effective silencing of triple...

Ferreira, Débora Carina Gonçalves Abreu; Pereira, Cátia Sofia Santos; Costa, Marta; Afonso, Julieta Alexandra Pereira; Yang, Sujuan; Hensel, Janine

Available online 28 September 2023; Triple negative breast cancer (TNBC) is a highly heterogenous disease not sensitive to endocrine or HER2 therapy and standardized treatment regimens are still missing. Therefore, development of novel TNBC treatment approaches is of utmost relevance. Herein, the potential of MAPK/ERK downregulation by RNAi-based therapeutics in a panel of mesenchymal stem-like TNBC cell lines ...


Glucose metabolism reprogramming in bladder cancer: hexokinase 2 (HK2) as progn...

Afonso, Julieta; Gonçalves, Céline; Costa, Marta; Ferreira, Débora Carina Gonçalves Abreu; Santos, Lúcio; Longatto-Filho, Adhemar; Baltazar, Fátima

Proliferating cancer cells are able to reprogram their energy metabolism, favouring glycolysis even in the presence of oxygen and fully functioning mitochondria. Research is needed to validate the glycolysis-related proteins as prognostic/predictive biomarkers in urothelial bladder carcinoma (UBC), a malignancy tagged by high recurrence rates and poor response to chemotherapy. Here, we assessed GLUT1, HK2, PFKL...


Electrochemical aptasensor for the detection of the key virulence factor YadA o...

Sande, Maria Georgina; Ferreira, Débora Carina Gonçalves Abreu; Rodrigues, Joana Lúcia Lima Correia; Melo, Luís Daniel Rodrigues; Linke, Dirk

New point-of-care (POC) diagnosis of bacterial infections are imperative to overcome the deficiencies of conventional methods, such as culture and molecular methods. In this study, we identified new aptamers that bind to the virulence factor Yersinia adhesin A (YadA) of Yersinia enterocolitica using cell-systematic evolution of ligands by exponential enrichment (cell-SELEX). Escherichia coli expressing YadA on ...


Identification of novel aptamers targeting cathepsin B-overexpressing prostate ...

Pereira, Ana Cláudia Santos; Pina, André F.; Sousa, Diana Andrade; Ferreira, Débora Carina Gonçalves Abreu; Cátia S. Pereira

Supplementary files: https://www.rsc.org/suppdata/d2/me/d2me00022a/d2me00022a1.pdf; Increased levels of cathepsin B (CatB), a cysteine protease, have been associated with different types of tumors, including prostate cancer. Hence, the identification of novel targeting ligands homing CatB may be a promising approach for the development of CatB-targeted therapies. In this work, a methodology called systematic ev...


New advances in exosome-based targeted drug delivery systems

Ferreira, Débora Carina Gonçalves Abreu; Moreira, João Nuno; Rodrigues, L. R.

Online ahead of print; In recent years, various drug nano-delivery platforms have emerged to enhance drug effectiveness in cancer treatment. However, their successful translation to clinics have been hampered by unwanted side effects, as well as associated toxicity. Therefore, there is an imperative need for drug delivery vehicles capable of surpassing cellular barriers and also efficiently transfer therapeutic...


In vitro selection of DNA aptamers against human osteosarcoma

Tsogtbaatar, Khaliunsarnai; Sousa, Diana Andrade; Ferreira, Débora Carina Gonçalves Abreu; Tevlek, Atakan; Aydin, Halil Murat; Çelik, Eda

Background. Osteosarcoma is a highly malignant bone tumor, most frequently occurring in the rapid bone growth phase. Effective treatment of this disease is hindered by the lack of specific probes for early diagnosis and the fast cancer widespread. Methods. To find such probes, the cell-Systematic Evolution of Ligands by EXponential enrichment (cell-SELEX) methodology was implemented against the human osteosarco...


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