16 documents found, page 1 of 2
Emerging lab-on-a-chip approaches for liquid biopsy in lung cancer: Status in c...
Carvalho, Â; Ferreira, G; Seixas, D; Guimarães-Teixeira, C; Henrique, R; Monteiro, FJ; Jerónimo, CDespite the intensive efforts dedicated to cancer diagnosis and treatment, lung cancer (LCa) remains the leading cause of cancer-related mortality, worldwide. The poor survival rate among lung cancer patients commonly results from diagnosis at late-stage, limitations in characterizing tumor heterogeneity and the lack of non-invasive tools for detection of residual disease and early recurrence. Henceforth, resea...
Peptide Receptor Radionuclide Therapy with 177 Lu-DOTA-TATE As a Promising Trea...
Magalhães, D; Sampaio, I; Ferreira, G; Bogalho, P; Martins-Branco, D; Santos, R; Duarte, HIntroduction: Insulinomas are a rare type of pancreatic neuroendocrine tumours characterized by insulin hypersecretion. They are considered malignant when metastases are present. Traditional therapies often promote only temporarily symptomatic relief and may be associated with severe adverse effects. There is scarce experience in treating malignant insulinomas with peptide receptors radionuclide therapy (PRRNT)...
Single-cell functional and chemosensitive profiling of combinatorial colorectal...
Fior, R; Póvoa, V; Mendes, V; Carvalho, T; Gomes, A; Figueiredo, N; Ferreira, GCancer is as unique as the person fighting it. With the exception of a few biomarker-driven therapies, patients go through rounds of trial-and-error approaches to find the best treatment. Using patient-derived cell lines, we show that zebrafish larvae xenotransplants constitute a fast and highly sensitive in vivo model for differential therapy response, with resolution to reveal intratumor functional cancer het...
The Calcium/Phosphorus Homeostasis in Chronic Kidney Disease: From Clinical Epi...
Pires, A; Sobrinho, L; Ferreira, GINTRODUCTION: A simple data filtering process together with some basic concepts of control theory applied to electronically stored clinical data were used to identify some of the pathophysiological mechanisms underlying the perturbations of the calcium/phosphorus homeostasis in chronic kidney disease. MATERIAL AND METHODS: Retrospective data (a set per patient of serum single value concentrations of creatinine,...
Metabolic Activity in the Visceral and Subcutaneous Adipose Tissues by FDG-PET/...
Monteiro, AM; Ferreira, G; Duarte, HINTRODUCTION: The emerging role of the 18F-fluorodeoxyglucose-positron emission tomography/computed tomography in the study of the metabolic activity and inflammation in adipose tissue indicates that it might be a reliable tool to complement the risk stratification in obesity. The aims of this study were the evaluation of 18F-fluorodeoxyglucose uptake by visceral adipose tissues and subcutaneous adipose tissues...
Genotype-phenotype correlation in a cohort of Portuguese patients comprising th...
Fidalgo, T; Salvado, R; Corrales, I; Pinto, SC; Borràs, N; Oliveira, A; Martinho, P; Ferreira, G; Almeida, H; Oliveira, C; Marques, D; Gonçalves, ElsaThe diagnosis of von Willebrand disease (VWD), the most common inherited bleeding disorder, is characterised by a variable bleeding tendency and heterogeneous laboratory phenotype. The sequencing of the entire VWF coding region has not yet become a routine practice in diagnostic laboratories owing to its high costs. Nevertheless, next-generation sequencing (NGS) has emerged as an alternative to overcome this li...
Genotype-phenotype correlation in a cohort of Portuguese patients comprising th...
Fidalgo, T; Salvado, R; Corrales, I; Pinto, SC; Borràs, N; Oliveira, A; Martinho, P; Ferreira, G; Almeida, H; Oliveira, C; Marques, D; Gonçalves, EThe diagnosis of von Willebrand disease (VWD), the most common inherited bleeding disorder, is characterised by a variable bleeding tendency and heterogeneous laboratory phenotype. The sequencing of the entire VWF coding region has not yet become a routine practice in diagnostic laboratories owing to its high costs. Nevertheless, next-generation sequencing (NGS) has emerged as an alternative to overcome this li...
Gastroenterite aguda em crianças internadas na área de Lisboa
Escobar, C; Silva, T; Costa, B; Oliveira, M; Correia, P; Ferreira, G; Costa, I; Júlio, C; Rodrigues, J; Machado, J; Marques, A; Simões, MJ; Oleastro, MIntrodução: A Gastroenterite Aguda (GEA) é uma patologia com importante morbilidade sendo a segunda causa de internamento na idade pediátrica. Objetivo: Caracterizar a GEA, em crianças internadas em dois hospitais da área de Lisboa com diferentes características demográficas. Métodos: Estudo prospetivo de maio 2011 a junho 2012. Pesquisados potenciais agentes etiológicos por técnicas convencionais e de biologia...
Blastic Plasmacytoid Dendritic Cell Neoplasm
Lencastre, A; Farinha, P; Cabete, J; Ferreira, G; João, A; Lestre, SBlastic plasmacytoid dendritic cell neoplasm is a rare and aggressive hematodermic neoplasia with frequent cutaneous involvement and leukemic dissemination. We report the case of a 76-year-old man with a 2 month history of violaceous nodules and a tumor with stony consistency, located on the head, and mandibular, cervical and supraclavicular lymphadenopathies. Multiple thoracic and abdominal adenopathies were i...
RSV infection – Risk factors, complications and treatment in two Portuguese hos...
Bento, V; Machado, R; Ferreira, M; Conde, M; Carreiro, H; Ferreira, G; Brito, MJAbstract. The aim of this study was to characterize the infection by respiratory syncytial virus (RSV), identify risk factors, complications and compare treatment strategies in children admitted to two Portuguese hospitals. It was a retrospective study performed between January 2005 and December 2006. Demographic and socioeconomic data, risk factors, treatment, compli- cations and medical follow-up were analyze...