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BRD9 status is a major contributor for cysteine metabolic remodeling through MS...

Hipólito, Ana; Xavier, Renato; Brito, Cheila; Tomás, Ana; Lemos, Isabel; Cabaço, Luís C.; Silva, Fernanda; Oliva, Abel; C. Barral, Duarte

Publisher Copyright: Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved.; Cutaneous melanoma (CM) is the most aggressive skin cancer, showing globally increasing incidence. Hereditary CM accounts for a significant percentage (5-15 %) of all CM cases. However, most familial cases remain without a known genetic cause. Even though, BRD9 has been associated to CM as a susceptibility gene. ...


Design and Biocompatibility of Biodegradable Poly(octamethylene suberate) Nanop...

de Barros, Dragana P.C.; Fonseca, Luís P.; Gonçalves, Luís G.; Serrano, Diogo S.; Oliva, Abel

Funding Information: This work was supported by FCT\u2014Funda\u00E7\u00E3o para a Ci\u00EAncia e a Tecnologia, I.P., through iNOVA4Health (DOI 10.54499/UIDB/04462/2020; DOI 10.54499/UIDP/04462/2020) and LS4FUTURE Associated Laboratory (DOI 10.54499/LA/P/0087/2020)\u201D. Publisher Copyright: © 2024 by the authors.; Biodegradable aliphatic polyester formulations as carriers for topical drug delivery show the po...


Safety of Gold Nanoparticles

Lopes, Joana; Ferreira-Gonçalves, Tânia; Ascensão, Lia; Viana, Ana S.; Carvalho, Lina; Catarino, José; Faísca, Pedro; Oliva, Abel

Funding Information: The authors acknowledge Fundação para a Ciência e a Tecnologia (FCT) for financial support through Projects UIDB/00645/2020, UIDB/04138/2020, UIDP/04138/2020, PTDC/BTM-MAT/31794/2017, and PTDC/QUI-QIN/0586/2020, as well as PhD fellowships SFRH/BD/148044/2019 and SFRH/BD/147306/2019. The authors are also thankful for the financial support to CESAM by FCT/MCTES (UIDP/50017/2020+UIDB/50017/202...


Reconstructed human pigmented skin/epidermis models achieve epidermal pigmentat...

Hall, Michael J; Lopes-Ventura, Sara; Neto, Matilde V; Charneca, João; Zoio, Patricia; C Seabra, Miguel; Oliva, Abel; C. Barral, Duarte

Funding: We thank the Electron Microscopy Facility at the Instituto Gulbenkian de Ciência, the Pathological Anatomy service in the Instituto Português de Oncologia de Lisboa Francisco Gentil (IPOLFG) and the Histology Facility at CEDOC for technical assistance. This project was supported by Fundação para a Ciência e a Tecnologia (FCT), Portugal through FCT Unit iNOVA4Health – UIDB/04462/2020 and UIDP/04462/2020...


Preparation and characterization of porous scaffolds based on poly(3-hydroxybut...

Esmail, Asiyah; Pereira, João R.; Sevrin, Chantal; Grandfils, Christian; Menda, Ugur Deneb; Fortunato, Elvira; Oliva, Abel; Freitas, Filomena

LA/P/0140/2020 iNOVA4Health/MULTI/04462/2018; Poly(hydroxyalkanoates) (PHAs) with different material properties, namely, the homopolymer poly(3-hydroxybutyrate), P(3HB), and the copolymer poly(3-hydroxybutyrate-co-3- hydroxyvalerate, P(3HB-co-3HV), with a 3HV of 25 wt.%, were used for the preparation of porous biopolymeric scaffolds. Solvent casting with particulate leaching (SCPL) and emulsion templating were ...


Oxygen plasma treated-electrospun polyhydroxyalkanoate scaffolds for hydrophili...

Esmail, Asiyah; Pereira, João R.; Zoio, Patrícia; Silvestre, Sara; Menda, Ugur Deneb; Sevrin, Chantal; Grandfils, Christian; Fortunato, Elvira

iNOVA4Health/MULTI/04462/2018; Poly(hydroxyalkanoates) (PHAs) with differing material properties, namely, the homo-polymer poly(3-hydroxybutyrate), P(3HB), the copolymer poly(3-hydroxybutyrate-co-3-hy-droxyvalerate), P(3HB-co-3HV), with a 3HV content of 25 wt.% and a medium chain length PHA, and mcl-PHA, mainly composed of 3-hydroxydecanoate, were studied as scaffolding material for cell culture. P(3HB) and P(3...


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