181 documents found, page 1 of 19
A crossinggram for random fields on lattices
Ferreira, Helena; Ferreira, Marta Susana; Alexandre, Luís A.The modeling of risk situations that occur in a space framework can be done using max-stable random fields on lattices. Although the summary coefficients for the spatial behavior do not characterize the finite-dimensional distributions of the random field, they have the advantage of being immediate to interpret and easier to estimate. The coefficients that we propose give us information about the tendency of a ...
The potential of the fibronectin inhibitor Arg-Gly-Asp-Ser in the development o...
Castro-Ribeiro, Maria L.; Castro, Vânia Isabel Baptista; Castro, Joana vieira de; Pires, R. A.; Reis, R. L.; Costa, Bruno M.; Ferreira, HelenaGlioblastoma (GBM) is the most lethal and common malignant primary brain tumor in adults. An important feature that supports GBM aggressiveness is the unique composition of its extracellular matrix (ECM). Particularly, fibronectin plays an important role in cancer cell adhesion, differentiation, proliferation, and chemoresistance. Thus, herein, a hydrogel with mechanical properties compatible with the brain and...
Characterization of Liquid Dosage Forms of Atenolol and Enalapril Maleate for O...
Mota, Sandra; Torres, Ana; Quintas, Clara; Peres, António M.; Ferreiro, Nuno Manuel; Cruz, Rebeca; Ferreira, Helena; Almeida, Isabel F.; Casal, SusanaThe limited availability of pharmaceutical formulations tailored for cardiovascular diseases in both pediatric and geriatric populations generates the need for compounded dosage forms to guarantee precise dosing and medication adherence. This study aimed to analyze the physicochemical properties and stability of formulations of atenolol and enalapril maleate prepared with a proprietary oral vehicle, SuspendIt®....
Urine metabolomics during a legume diet intervention suggests altered metabolic...
Ferreira, Helena; Duarte, Daniela; Rodrigues, João A.; Vasconcelos, Marta W.; Pinto, Elisabete; Gil, Ana M.Given the general increase in legume consumption worldwide, there is a need to characterize the resulting human metabolic adaptations in order to demonstrate potential legume diet/health relationships. A nuclear magnetic resonance (NMR) metabolomics urine study was carried out on a small cohort (n = 18) to characterize the excretory effects of a pilot longitudinal 8-week legume-based dietary intervention. Despi...
Impact of a legumes diet on the human gut microbiome articulated with fecal and...
Ferreira, Helena; Duarte, Daniela; Carneiro, Tatiana J.; Costa, Célia; Barbosa, Joana C.; Rodrigues, João E.; Alves, Paulo; Vasconcelos, MartaBackground & aims: Legumes intake is known to be associated with several health benefits the origins of which is still a matter of debate. This paper addresses a pilot small cohort to probe for metabolic aspects of the interplay between legumes intake, human metabolism and gut microbiota. Methods: Untargeted nuclear magnetic resonance (NMR) metabolomics of blood plasma and fecal extracts was carried out, in tan...
Impact of a daily legume-based meal on blood and anthropometric parameters in a...
Ferreira, Helena; Vasconcelos, Marta; Gil, Ana M.; Silveira, Joana; Alves, Paulo; Martins, Sandra; Assunção, Marco; Guimarães, João TiagoThis pilot study aimed to assess the impact of substituting a traditional lunch for a vegetarian legume-based meal on blood and anthropometric parameters in a group of omnivorous adults. A one-group comparison, quasi-experimental dietary intervention was designed. A vegetarian legume-based meal was offered for 8 consecutive weeks (weekdays) to non-vegetarian individuals (n = 26), (28 years [P25 = 20.0, P75 = 35...
Tracking Narrative Change in Post-intervention Focus Groups for Teachers: an ex...
Silva, Joana; Batista, João; Fernández-Navarro, Pablo; Ferreira, Helena; Palmeira, Lara; Albuquerque, Isabel; Galhardo, Ana; Cunha, MarinaReliable and systematic qualitative methodologies to assess participants’ change after group interventions are scarce. This study outlines a methodolo5gical approach to use in focus groups, allowing the elicitation and coding of participants’ change talk after a group intervention. A Change Elicitation Script for Focus Groups was developed and its viability for evoking participants’ discussion around change was...
Exploring seaweed and Glycine Betaine Biostimulants for enhanced phenolic conte...
Monteiro, Eliana Maria Ribeiro; De Lorenzis, Gabriella; Ricciardi, Valentina; Baltazar, Miguel; Pereira, Sandra; Correia, Sofia Mendes MoreiraClimate change will pose a challenge for the winemaking sector worldwide, bringing progressively drier and warmer conditions and increasing the frequency and intensity of weather extremes. The short-term adaptation strategy of applying biostimulants through foliar application serves as a crucial measure in mitigating the detrimental effects of environmental stresses on grapevine yield and berry quality. The aim...
On the size-dependent internalization of sub-hundred polymeric nanoparticles
Gimondi, Sara; Castro, Joana Isabel Martins Cosme Vieira; Reis, R. L.; Ferreira, Helena; Neves, N. M.The understanding of the interaction between nanoparticles (NPs) and cells is crucial to design nanocarriers with high therapeutic relevance. In this study, we exploited a microfluidics device to synthesize homogeneous suspensions of NPs with ≈ 30, 50, and 70 nm of size. Afterward, we investigated their level and mechanism of internalization when exposed to different types of cells (endothelial cells, macrophag...
Microfluidic devices: a tool for nanoparticle synthesis and performance evaluation
Gimondi, S.; Ferreira, Helena; Reis, R. L.; Neves, N. M.The use of nanoparticles (NPs) in nanomedicine holds great promise for the treatment of diseases for which conventional therapies present serious limitations. Additionally, NPs can drastically improve early diagnosis and follow-up of many disorders. However, to harness their full capabilities, they must be precisely designed, produced, and tested in relevant models. Microfluidic systems can simulate dynamic flu...