63 documents found, page 1 of 7

Movement biomechanics and lateralisation in dart throwing

Gold nanoparticles: a promising next-generation tool for breast cancer photothe...

AuNPs show suitable mean sizes and maximum absorbance peaks to be used for PTT when locally administered. AuNPs show no toxicity either in breast cancer cell lines or red blood cells. Laser irradiation proved to be safe when applied alone. Combining EGF-conjugated AuNPs with laser irradiation resulted in a reduction of 33% in MCF-7 cells viability. The animal model was successfully developed (all animals develo...

A Case Study of a Solar Oven’s Efficiency: An Experimental Approach

This research presents the design, construction, and experimental evaluation of a novel box-type solar oven optimized for enhanced thermal efficiency and heat retention, developed to address the challenges of sustainable cooking in temperate climates. The solar oven, measuring 120 cm × 60 cm × 45 cm, incorporates strategically designed rock wool insulation and 5 kg of steel plates as thermal mass, along with a ...

Chimeric Antigen Receptor T‐Cell Therapy: Potentially Nephrotoxic?

Introduction: Chimeric antigen receptor (CAR) T‐cell therapy is an effective new treatment for hematologic malignan‐ cies. In this study, we aimed to characterize the acute kidney injury (AKI) and electrolyte disorders among adults with refractory and relapsed haematological malignancies treated with CAR‐T therapy and explore clinical outcomes. Methods: A retrospective, observational study was performed. Adult ...

Does it bug you eating bugs? The emotions of anthropoentomophagy

The use of insects as food is a proposed solution for the increased demand for food worldwide, but it lacks acceptance because of restrictive emotional factors. This article aims to understand better customers’ emotions’ role in considering and consuming insect-based food. Design/methodology/approach – To assess their acceptance, an experiment was developed with 38 participants living in Portugal to identify ho...

Severe acute kidney injury in hospitalized cancer patients: epidemiology and pr...

Background: Acute kidney injury (AKI) is a common complication among cancer patients, often leading to longer hospital stays, discontinuation of cancer treatment, and a poor prognosis. This study aims to provide insight into the incidence of severe AKI in this population and identify the risk factors associated with renal replacement therapy (RRT) and in-hospital mortality. Methods: This retrospective cohort st...

Acute kidney injury after cytoreductive surgery and hyperthermic intraperitonea...

Background: Acute kidney injury (AKI) after cytoreductive surgery followed by the infusion of hyperthermic intraperitoneal chemothera-py (CRS/HIPEC) is associated with a higher rate of major complica-tions, resulting in prolonged hospitalization and increased mortality. Our objective was to evaluate the incidence of AKI and further pro-gression to chronic kidney disease (CKD) in patients submitted to this proce...

Normative modelling detects abnormal functional connectivity in schizophrenia

Machine learning (ML) applications on the diagnosis of neuropsychiatric disorders (NPD) have not reached clinical practice yet, as the continuous spectrum of NPD demands more complex, non-binary classification approaches. Herein, a ML-based normative model was created from healthy subjects, which “fails” when tested on schizophrenia patients. In particular, abnormal functional connectivity patterns were found i...

Stage-independent biomarkers for Alzheimer’s disease from the living retina: an...

The early diagnosis of neurodegenerative disorders is still an open issue despite the many efforts to address this problem. In particular, Alzheimer’s disease (AD) remains undiagnosed for over a decade before the first symptoms. Optical coherence tomography (OCT) is now common and widely available and has been used to image the retina of AD patients and healthy controls to search for biomarkers of neurodegenera...

Shedding light on early central nervous system changes for Alzheimer’s disease ...

The World Health Organization (WHO) 2015 projections estimated 75.6 million people living with dementia in 2030, an update from the 66 million estimated in 2013. These figures account for all types of dementia, but Alzheimer’s disease stands out as the most common estimated type, representing 60% to 80% of the cases. An increasing number of research groups adopted the approach of using the retina as a window to...