10 documents found, page 1 of 1
Mitochondrial and Redox Changes in Periodontitis and Type 2 Diabetes Human Bloo...
Ferreira, Ildete L.; Costa, Solange; Moraes, Bruno; Costa, Ana; Fokt, Olga; Marinho, Daniela; Alves, Vera; Baptista, Isabel P.; Rego, A. CristinaPeriodontitis (PDT) and type 2 diabetes (T2D) have demonstrated a bidirectional relationship and imbalanced oxidative stress linked to mitochondrial dysfunction. Therefore, we investigated mitochondrial and redox (de)regulation in peripheral blood mononuclear cells (PBMCs) in comorbid T2D-PDT, compared to PDT, T2D patients, and control individuals. PBMCs were analyzed for mitochondrial respiration, reactive oxy...
Footprints of a microbial toxin from the gut microbiome to mesencephalic mitoch...
Esteves, A. Raquel; Munoz-Pinto, Mário F; Nunes-Costa, Daniela; Candeias, Emanuel; Silva, Diana F. F.; Magalhães, João Duarte; Santos, A. Raquel PereiraObjective Idiopathic Parkinson’s disease (PD) is characterised by alpha-synuclein (aSyn) aggregation and death of dopaminergic neurons in the midbrain. Recent evidence posits that PD may initiate in the gut by microbes or their toxins that promote chronic gut inflammation that will ultimately impact the brain. In this work, we sought to demonstrate that the effects of the microbial toxin β-N- methylamino- L- al...
Mitochondrial Dysfunction and Decreased Cytochrome c in Cell and Animal Models ...
Almeida, Filipa; Ferreira, Ildete L.; Naia, Luana; Marinho, Daniela; Vilaça-Ferreira, Ana Catarina; Costa, Marta D.; Duarte-Silva, SaraMitochondrial dysfunction has been described in many neurodegenerative disorders; however, there is less information regarding mitochondrial deficits in Machado-Joseph disease (MJD), a polyglutamine (polyQ) disorder caused by CAG repeat expansion in the ATXN3 gene. In the present study, we characterized the changes in mitochondrial function and biogenesis markers in two MJD models, CMVMJD135 (MJD135) transgenic...
Reduction of class I histone deacetylases ameliorates ER-mitochondria cross-tal...
Marinho, Daniela; Ferreira, Ildete L.; Lorenzoni, Ricardo; Cardoso, Sandra M.; Santana, Isabel; Rego, A. CristinaSeveral molecular mechanisms have been described in Alzheimer's disease (AD), including repressed gene transcription and mitochondrial and endoplasmic reticulum (ER) dysfunction. In this study, we evaluate the potential efficacy of transcriptional modifications exerted by inhibition or knockdown of class I histone deacetylases (HDACs) in ameliorating ER-mitochondria cross-talk in AD models. Data show increased ...
Simultaneous Alteration of the Circadian Variation of Memory, Hippocampal Synap...
Carvalho da Silva, António M; Lemos, Cristina; Silva, Henrique Bernardo; Ferreira, Ildete L.; Tomé, Ângelo R.; Rego, A. Cristina; Cunha, Rodrigo A.Alzheimer's disease (AD) is characterized by progressive memory deficits accompanied by synaptic and metabolic deficits, namely of mitochondrial function. AD patients also display a disrupted circadian pattern. Thus, we now compared memory performance, synaptic plasticity, and mitochondria function in 24-week-old non-transgenic (non-Tg) and triple transgenic male mice modeling AD (3xTg-AD) at Zeitgeber 04 (ZT-4...
Boldine Attenuates Synaptic Failure and Mitochondrial Deregulation in Cellular ...
Toledo, Juan P.; Fernández-Pérez, Eduardo J.; Ferreira, Ildete L.; Marinho, Daniela; Riffo-Lepe, Nicolas O.; Pineda-Cuevas, Benjamin N.Alzheimer's disease (AD) is the most common cause of senile dementia worldwide, characterized by both cognitive and behavioral deficits. Amyloid beta peptide (Aβ) oligomers (AβO) have been found to be responsible for several pathological mechanisms during the development of AD, including altered cellular homeostasis and synaptic function, inevitably leading to cell death. Such AβO deleterious effects provide a ...
Dysfunctional synapse in Alzheimer’s disease – a focus on NMDA receptors
Mota, Sandra I.; Ferreira, Ildete L.; Rego, A. CristinaAlzheimer's disease (AD) is the most prevalent form of dementia in the elderly. Alterations capable of causing brain circuitry dysfunctions in AD may take several years to develop. Oligomeric amyloid-beta peptide (Aβ) plays a complex role in the molecular events that lead to progressive loss of function and eventually to neurodegeneration in this devastating disease. Moreover, N-methyl-d-aspartate (NMDA) recept...
Consequences of mitochondrial dysfunction in Huntington's Disease and protectio...
Cunha-Oliveira, Teresa; Ferreira, Ildete L.; Rego, A. CristinaHuntington’s Disease (HD) is an autosomal dominant neurodegenerative disorder clinically characterized by psychiatric disturbances, progressive cognitive impairment and choreiform movements. These symptoms are associated with the selective atrophy and neuronal loss in the striatum, cortex and hypothalamus. The disease is caused by a mutation at the 5’ terminal of the huntingtin (HTT) gene involving the expansio...
Northeast Portuguese propolis protects against neurotoxic events in cerebral co...
Cardoso, Susana M.; Ribeiro, Marcio; Ferreira, Ildete L.; Falcão, Soraia; Vilas-Boas, Miguel; Rego, Ana C.Propolis is a sticky substance that honeybees manufacture by mixing secreted substances from their metabolism with plant exudates, pollen and waxes. This product has been used in folk medicine for centuries. Currently, it is extensively used in foods and beverages and is claimed to improve human health. Propolis is known to have a wide range of biological properties, including anti-microbial, anti-inflammatory,...
Glutamate in Life and Death of Retinal Amacrine Cells*
Duarte, Carlos B.; Ferreira, Ildete L.; Santos, Paulo F.; Carvalho, Ana L.; Agostinho, Paula M.; Carvalho, Arsélio P.1. Glutamate is the neurotransmitter released by bipolar cells at their synapses with amacrine cells. The amacrine cells express ionotropic (NMDA, AMPA and kainate) and metabotropic (mGluR1, mGluR2, mGluR4 and mGluR7) glutamate receptors and may take up glutamate from the synaptic cleft.; http://www.sciencedirect.com/science/article/B6T71-3WDCGNH-6/1/585429baef39660288a51842ff1b4c33