29 documents found, page 1 of 3
Pd(II) and Pt(II) Trinuclear Chelates with Spermidine: Selective Anticancer Act...
Vojtek, Martin; Martins, Clara B.; Ramos, Raquel; Duarte, Sara Gomes; Ferreira, Isabel M. P. L. V. O.; Carvalho, Ana L. M. Batista deTriple-negative breast cancer (TNBC) is one of the most aggressive forms of breast cancer and constitutes 10-20% of all breast cancer cases. Even though platinum-based drugs such as cisplatin and carboplatin are effective in TNBC patients, their toxicity and development of cancer drug resistance often hamper their clinical use. Hence, novel drug entities with improved tolerability and selectivity profiles, as w...
The improved quality of gluten-free bread due to the use of flaxseed oil cake: ...
Oliveira, Daniela; Starowicz, Małgorzata; Ostaszyk, Anita; Łopusiewicz, Łukasz; Ferreira, Isabel M. P. L. V. O.; Pinto, Edgar; Krupa-Kozak, UrszulaThe development of gluten-free bakery products, the quality of which is comparable to the quality of regular wheat-based products, remains a technological challenge. In this study, flaxseed oil cake (FOC), a by-product of flaxseed oil extraction and a source of nutritional and functional compounds, was used as an ingredient in the experimental bread formulation as partial replacement of starches (5%, 15%, and 3...
Brewer's yeast as a clean label ingredient for replacement of phosphates in hams
Tomaz, Samuel A.; Machado Jr, Júlio C.; Dias, Joana Sofia Gomes; Pereira, Ricardo Nuno Correia; Rocha, Cristina M. R.; Ferreira, Isabel M. P. L. V. O.Phosphates are common additives in the meat industry. They are used to increase the water retention capacity. They act in buffering, emulsification, colour stability, inhibition of lipid oxidation, antibacterial activity and protein dispersing properties. Excessive consumption inhibits absorption of minerals, causes kidney diseases and colorectal cancer. Brewer's yeasts are sets of strains responsible for beer ...
Upcycling rocha do Oeste pear pomace as a sustainable food ingredient: composit...
Fernandes, Ana; Simões, Sara; Ferreira, Isabel M. P. L. V. O.; Alegria, Maria João; Mateus, Nuno; Raymundo, Anabela; Freitas, Victor deThis work explores the potential of Rocha do Oeste pear pomace to be used as a sustainable and healthy food ingredient. Moreover, the enrichment with yeast protein extract (YPE) may be useful to design innovative food products. The main goals of this study were to assess pear pomace concerning: (i) chemical composition and antioxidant capacity; (ii) rheology, texture, and microstruc- ture characterization (alon...
Assessment of paracetamol toxic effects under varying seawater pH conditions on...
Daniel, David; Nunes, Bruno; Pinto, Edgar; Ferreira, Isabel M. P. L. V. O.; Correia, Alberto TeodoricoIncreasing atmospheric carbon dioxide (CO2) levels are likely to lower ocean pH values, after its dissolution in seawater. Additionally, pharmaceuticals drugs are environmental stressors due to their intrinsic properties and worldwide occurrence. It is thus of the utmost importance to assess the combined effects of pH decreases and pharmaceutical contamination, considering that their absorption (and effects) ar...
Nutritional characterization of Strychnos madagascariensis fruit flour produced...
Chemane, Sandra S. I.; Ribeiro, Mafalda; Pinto, Edgar; Pinho, Susana C. M.; Martins, Zita Sá; Almeida, Agostinho; Ferreira, Isabel M. P. L. V. O.The indigenous fruit Strychnos madagascariensis is usually processed to flour, called nfuma, being highly consumed during staple food shortage. This study aimed to evaluate the nutritional composition of nfuma and its nutrient adequacy. Flours from four districts of Mozambique were analyzed using AOAC methods for proximate composition, HPLC for sugar, amino acids (AA), vitamin E and carotenoids and ICP-MS and F...
Preclinical Pharmacokinetics and Biodistribution of Anticancer Dinuclear Pallad...
Vojtek, Martin; Gonçalves-Monteiro, Salomé; Pinto, Edgar; Kalivodová, Sára; Almeida, Agostinho; Marques, Maria P. M.; Batista de Carvalho, Ana L. M.Palladium-based compounds are regarded as potential analogs to platinum anticancer drugs with improved properties. The present study assessed the pharmacokinetics and biodistribution of a dinuclear palladium(II)-spermine chelate (Pd2Spm), which has previously been shown to possess promising in vitro activity against several therapy-resistant cancers. Using inductively coupled plasma-mass spectrometry, the kinet...
Preclinical pharmacokinetics and biodistribution of Anticancer Dinuclear Pallad...
Vojtek, Martin; Gonçalves-Monteiro, Salomé; Pinto, Edgar; Kalivodová, Sára; Almeida, Agostinho; Marques, Maria P. M.; Carvalho, Ana L. M. Batista dePalladium-based compounds are regarded as potential analogs to platinum anticancer drugs with improved properties. The present study assessed the pharmacokinetics and biodistri bution of a dinuclear palladium(II)-spermine chelate (Pd2Spm), which has previously been shown to possess promising in vitro activity against several therapy-resistant cancers. Using inductively coupled plasma-mass spectrometry, the kine...
Preclinical pharmacokinetics and biodistribution of anticancer dinuclear Pallad...
Vojtek, Martin; Gonçalves-Monteiro, Salomé; Pinto, Edgar; Kalivodová, Sára; Almeida, Agostinho; Marques, Maria P. M.; Batista de Carvalho, Ana L. M.Palladium-based compounds are regarded as potential analogs to platinum anticancer drugs with improved properties. The present study assessed the pharmacokinetics and biodistribution of a dinuclear palladium(II)-spermine chelate (Pd2Spm), which has previously been shown to possess promising in vitro activity against several therapy-resistant cancers. Using inductively coupled plasma-mass spectrometry, the kinet...
Fish Oil Enzymatic Esterification for Acidity Reduction
Mata, Teresa M.; Correia, Daniela; Andrade, Soraia; Casal, Susana; Ferreira, Isabel M. P. L. V. O.; Matos, Elisabete; Martins, António A.The reduction of the fish oil acidity is a significant problem in the rendering industry, as the oil’s range of applications and market value strongly depend on this parameter. In particular, the lower the acidity, the larger the oil’s market value. This work aims to study the potential of enzymatic esterification for reducing the fish oil acidity, by converting the free fatty acids into esters. Thus, four comm...