90 documents found, page 1 of 9
Tumor-Infiltrating T Cells in Skin Basal Cell Carcinomas and Squamous Cell Carc...
Cunha, D; Neves, M; Silva, D; Silvestre, AR; Nunes, PB; Arrobas, F; Ribot, JC; Ferreira, F; Moita, LF; Soares-de-Almeida, L; Silva, JM; Filipe, PBasal cell carcinomas (BCCs) and squamous cell carcinomas (SCCs) are high-incidence, non-melanoma skin cancers (NMSCs). The success of immune-targeted therapies in advanced NMSCs led us to anticipate that NMSCs harbored significant populations of tumor-infiltrating lymphocytes with potential anti-tumor activity. The main aim of this study was to characterize T cells infiltrating NMSCs. Flow cytometry and immuno...
Outcomes of ventricular tachycardia ablation in patients with ischemic and non-...
Gomes, DA; Paiva, MS; Matos, D; Bello, AR; Rodrigues, G; Carmo, J; Ferreira, J; Moscoso Costa, F; Galvão Santos, P; Carmo, P; Cavaco, DIntroduction and objectives: Catheter ablation (CA) is effective in the treatment of ventricular tachycardia (VT). Although some observational data suggest patients with non-ischemic cardiomyopathy (NICM) have less favorable outcomes when compared to those with an ischemic etiology (ICM), direct comparisons are rarely reported. We aimed to compare the outcomes of VT ablation in a propensity score matched popula...
Sociodemographic, Clinical, and Behavioral Factors Associated With Sexual Trans...
Miranda, M; Pimentel, V; Graça, J; Seabra, S; Sebastião, C; Diniz, A; Faria, D; Teófilo, E; Roxo, F; Maltez, F; Germano, I; Oliveira, J; Ferreira, JIntroduction: Sexually transmitted infections (STIs) continue to occur at high levels. According to the WHO, each year there are an estimated 374 million new infections with syphilis, gonorrhea, chlamydia, and trichomoniasis. STIs are associated with an increased risk of acquiring HIV infection. Migrants are reportedly highly affected by STIs. Objectives: This study aims to characterize factors associated with ...
Towards user-centered design of medical devices for SUDEP prediction and preven...
Ferreira, J; França, M; Rei, M; Peixoto, R; Armand Larsen, S; Bernini, A; Lopes, L; Conde, C; Claro, JObjectives: As epilepsy management medical devices emerge as potential technological solutions for prediction and prevention of sudden death in epilepsy (SUDEP), there is a gap in understanding the features and priorities that should be included in the design of these devices. This study aims to bridge the gap between current technology and emerging needs by leveraging insights from persons with epilepsy (PWE) ...
Complete blood count parameters as biomarkers of retinopathy of prematurity: a ...
Fevereiro-Martins, M; Santos, AC; Marques-Neves, C; Guimarães, H; Bicho, M; Afonso, C; Ferreira, J; Espírito Santo, R; Teixeira, F; Rosa, RPurpose: To evaluate complete blood count (CBC) parameters in the first week of life as predictive biomarkers for the development of retinopathy of prematurity (ROP). Methods: Multicenter, prospective, observational study of a cohort of preterm infants born with gestational age (GA) < 32 weeks or birth weight < 1500 g in eight Portuguese neonatal intensive care units. All demographic, clinical, and laboratory d...
Efficacy and safety of pharmacological interventions for managing sickle cell d...
Tonin, FS; Ginete, C; Fernandez-Llimos, F; Ferreira, J; Delgadinho, M; Brito, MIntroductionSickle cell disease (SCD), an inherited haemoglobinopathy, has important impact on morbidity and mortality, especially in paediatrics. Previous systematic reviews are limited to adult patients or focused only on few therapies. We aim to synthesise the evidence on efficacy and safety of pharmacological interventions for managing SCD in children and adolescents.Methods and analysisThis systematic revi...
Efficacy and safety of pharmacological interventions for managing sickle cell d...
Tonin, FS; Ginete, C; Ferreira, J; Delgadinho, M; Santos, B; Fernandez-Llimos, F; Brito, MThis study aimed to synthesize the evidence on the effects of disease-modifying agents for managing sickle cell disease (SCD) in children and adolescents by means of a systematic review with network meta-analyses, surface under the cumulative ranking curve (SUCRA) and stochastic multicriteria acceptability analyses (SMAA) (CRD42022328471). Eightteen randomized controlled trials (hydroxyurea [n = 7], l-arginine ...
HIV-1-Transmitted Drug Resistance and Transmission Clusters in Newly Diagnosed ...
Pingarilho, M; Pimentel, V; Miranda, M; Silva, AR; Diniz, A; Ascenção, B; Piñeiro, C; Koch, C; Rodrigues, C; Caldas, C; Morais, C; Faria, DObjective: To describe and analyze transmitted drug resistance (TDR) between 2014 and 2019 in newly infected patients with HIV-1 in Portugal and to characterize its transmission networks. Methods: Clinical, socioepidemiological, and risk behavior data were collected from 820 newly diagnosed patients in Portugal between September 2014 and December 2019. The sequences obtained from drug resistance testing were us...
Late Onset Neuromyelitis Optica Spectrum Disorders (LONMOSD) from a Nationwide ...
Santos, E; Moura, J; Samões, R; Sousa, AP; Mendonça, T; Abreu, P; Guimarães, J; Correia, I; Durães, J; Sousa, L; Ferreira, J; de Sá, J; Sousa, FIntroduction: Several neuroimmunological disorders have distinct phenotypes according to the age of onset, as in multiple sclerosis or myasthenia gravis. It is also described that late onset NMOSD (LONMOSD) has a different phenotype. Objective: To describe the clinical/demographic characteristics of the LONMOSD and distinguish them from those with early onset (EONMOSD). Methods: From a nationwide Portuguese NMO...
REALMS Study: Real-World Effectiveness and Safety of Fingolimod in Patients wit...
Batista, S; Nunes, CC; Cerqueira, JJ; Martins Silva, A; Correia de Sá, J; Ferreira, J; Mendonça, MT; Pinheiro, J; Salgado, V; Correia, AS; Sequeira, JBackground: Fingolimod, an oral sphingosine 1-phosphate receptor modulator, is approved by EMA for relapsing-remitting multiple sclerosis (RRMS). Objectives: To assess the effectiveness and safety of fingolimod in patients with RRMS in real-world clinical practice in Portugal. Methods: Retrospective, multicentre, non-interventional study, reporting 3 years follow-up of data collected from October 2015 to July 2...