The way trial results are reported affects the physician's decisions. We describe some methods for the critical appraisal of clinical trial results (relative risk, absolute risk reduction, number needed to treat, confidence intervals, etc.).; The way trial results are reported affects the physician's decisions. We describe some methods for the critical appraisal of clinical trial results (relative risk, absolut...
This is the first of two articles concerning the techniques of critical appraisal of controlled clinical trials. It presents an overview of the delicate points of the following issues: operational questions; definition of primary and secondary variables, classification of the trial as pragmatic or explanatory, selection of the population sample, study design and its appropriateness to the goals, sample size and...
This paper reviews Cochrane Collaboration and its structure. The authors explain the concepts of systematic review and meta-analysis. Some insights are provided on how products of the Cochrane Collaboration, namely the Cochrane Library, can contribute to the practice of Evidence-Based Medicine.; This paper reviews Cochrane Collaboration and its structure. The authors explain the concepts of systematic review an...
Syphilis in HIV-infected patients reveals some particular aspects which are clinically relevant and disturbing: it is more frequent and develops more quickly to late stages, namely neurosyphilis; this progression may happen even if classic therapy in the early stages has been undertaken; the diagnosis of neurosyphilis is rather complex, the serological tests being of no definite credit; high doses of intravenou...