4 documents found, page 1 of 1
Nucleus-Cytoskeleton Crosstalk During Mitotic Entry
Dantas, M; Lima, JT; Ferreira, JGIn preparation for mitosis, cells undergo extensive reorganization of the cytoskeleton and nucleus, so that chromosomes can be efficiently segregated into two daughter cells. Coordination of these cytoskeletal and nuclear events occurs through biochemical regulatory pathways, orchestrated by Cyclin-CDK activity. However, recent studies provide evidence that physical forces are also involved in the early steps o...
The intertidal zone of the North-East Atlantic region: pattern and process.
Hawkins, SJ; Pack, KE; Firth, LB; Mieskowska, N; Evans, AJ; Martins, GM; Aberg, P; Adams, LC; Arenas, F; Boaventura, DM; Bohn, K; Borges, CDGThe north-east Atlantic region is an area where clades originating in the north Pacific (fucoids, balanoids, littorinids, thaids, laminarians) collide with clades from further south in the Atlantic (e.g., patellids, trochids, chthamalids). At high latitudes in the north, seaweeds dominate the midshore zone of all but the most exposed shores. Further south, midshore space-occupying invertebrates (mussels and bar...
Spatiotemporal control of mitotic exit during anaphase by an aurora B-Cdk1 cros...
Afonso, O; Castellani, CM; Cheeseman, LP; Ferreira, JG; Orr, B; Ferreira, LT; Chambers, JJ; Morais-de-Sá, E; Maresca, TJ; Maiato, HAccording to the prevailing ‘clock’ model, chromosome decondensation and nuclear envelope reformation when cells exit mitosis are byproducts of Cdk1 inactivation at the metaphase-anaphase transition, controlled by the spindle assembly checkpoint. However, mitotic exit was recently shown to be a function of chromosome separation during anaphase, assisted by a midzone Aurora B phosphorylation gradient-the ‘ruler’...
Acto-myosin force organization modulates centriole separation and PLK4 recruitm...
Vitiello, E; Moreau, P; Nunes, V; Mettouchi, A; Maiato, H; Ferreira, JG; Wang, I; Balland, MThe presence of aberrant number of centrioles is a recognized cause of aneuploidy and hallmark of cancer. Hence, centriole duplication needs to be tightly regulated. It has been proposed that centriole separation limits centrosome duplication. The mechanism driving centriole separation is poorly understood and little is known on how this is linked to centriole duplication. Here, we propose that actin-generated ...