Objective: The present work is an analytical and prospective study on the determination of HDL-cholesterol through two different methodologies, precipitation and direct method, in a group of 51 patients attended by a school laboratory. Method: For the determination of these analytes, two methodologies were used: direct method and precipitation method, because it has been observed experimentally discrepancies in...
OBJECTIVES: Characterize the cell profile and immunostaining of proinflammatory markers in an experimental model of bisphosphonate-related osteonecrosis of the jaw (BRONJ). MATERIALS AND METHODS: Male Wistar rats (n = 6– 7) were treated chronically with saline solution or zoledronic acid (ZA) at 0.04, 0.20, and 1.00 mg kg 1 (1.4 3 10 7, 6.9 3 10 6, and 3.4 3 10 5 mol kg 1), and subsequently, the first left inferio...
Eleven phthalimide derivatives were evaluated with regards to their antiproliferative activity on tumor and normal cells and possible toxic effects. Cytotoxic analyses were performed against murine tumors (Sarcoma 180 and B-16/F-10 cells) and peripheral blood mononuclear cells (PBMC) using MTT and Alamar Blue assays. Following, the investigation of cytotoxicity was executed by flow cytometry analysis and antitu...