Objectives: Tuberculosis is the main cause of death by a single infectious agent in the world. However, few studies have been published about the anatomopathological aspects of tuberculosis (TB) in the organism as a whole. The objective of this article is to analyze the anatomopathological characteristics of deceased patients diagnosed with tuberculosis revealed by autopsy and their relationship with epidemiolo...
Introdução: a necrópsia garante a acurácia estatística de mortalidade, esclarece mortes não explicadas, é fonte de aprendizado, de pesquisa e controle de qualidade hospitalar. Objetivos: verificar a frequência de necrópsias no Departamento de Patologia e Medicina Legal da Universidade Federal do Ceará (DPML/UFC), avaliar a eficácia diagnóstica da necrópsia, concordância e discordância entre o diagnóstico clínic...
Background Gastric cancer results from a multifactorial process and is one of the most common causes of death worldwide. These tumors can arise in the distal stomach (non-cardia) and in the cardia region, presenting different characteristics and frequency of occurrence worldwide. Aims To search for differences between tumors of dif- ferent locations that could explain the presence of cardia tumors, considering ...
FERREIRA, M. V. P. Frutalina, lectina α-D galactose ligante de Artocarpus incisa L.: um estudo com câncer de mama. 2001. 99 f. Tese (Doutorado em Bioquímica) - Centro de Ciências, Departamento de Bioquímica e Biologia Molecular, Universidade Federal do Ceará, Fortaleza, 2001.; Lectins are proteins which bind specifically to carbohydrates. Recently considerable interest has been devoted to cell surface carbohydr...
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Evidence suggests that the carcinogenic process guided by Helicobacter pylori is related to the expression of cell cycle and apoptosis proteins as BCL-2, BAX, and MYC. However, the literature is conflicting regarding the expression frequency in the histological subtypes and did not consider cagA gene presence. To investigate the expression of these proteins considering the histological subtypes of gastric cance...
ackground: The association between Helicobacter pylori gene diversity and gastric cancer has been poorly reported, although it is one of the important ways to explain the gastric pathogenesis. The aim of this study was to investigate the frequency of cag E and vir B11 genes in H. pylori isolated from patients with gastric cancer and to analyze the histology profiles. Materials and methods: The presence of H. py...
Objective. Decreases in p27 KIP1 and C-MYC expression have been associated with Helicobacter pylori infection. Furthermore, C-MYC seems to be a transcriptional repressor of p27 KIP1 . Therefore, in a series of gastric adenocarcinomas we studied the association of p27 KIP1 expression with H. pylori genotype ( vac A, cag A, cag E and vir B11) and the involvement of C-MYC in this process. Material and methods. Exp...
AIM: To investigate the interrelationship between H pylori and Epstein-Barr virus (EBV) infection in the gastric carcinogenesis having in focus the p53 mutation and the c-Myc, Bcl-2 and Bax expression. METHODS: seventy-one gastric carcinoma tissues were assessed by polymerase chain reaction (PCR) for H pylori and in situ hybridization for EBV. c-Myc, Bcl-2 and Bax expression were detected by immunohistochemistr...