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Helicobacter pylori genotype and polymorphisms in DNA repair enzymes : where do...
Silva-Fernandes, Isabelle Joyce de Lima; Silva, Thayse Azevedo da; Agnez-Lima, Lucymara Fassarella; Ferreira, Márcia Valéria PitomveiraOne of the mechanisms proposed by which H. pylori causes gastric cancer (GC) is through DNA damage due to chronic inflammation. Genomic integrity is guaranteed by repair enzymes such as APE-1, OGG-1, and PARP-1. Host genetic polymorphisms associated with the bacterial strain may influence the ability to repair the damage, contributing to the development of H. pylori-associated GC. The aim of this study was to d...
Date: 2013
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Origin: Oasisbr