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Effectiveness of photodynamic therapy on treatment response and survival of pat...

Cardoso, Miguel; Marto, Carlos Miguel; Paula, Anabela; Coelho, Ana Sofia; Pinho e Melo, Teresa M. V. D.; Ferreira, Manuel M.; Botelho, Maria Filomena

Objective: This review aims to systematically examine the effectiveness of photodynamic therapy for the treatment of patients with recurrent oral squamous cell carcinoma. Introduction: Oral squamous cell carcinoma is a significant public health problem, and is the seventh most common cancer. Its incidence is mainly due to tobacco use, alcohol consumption, and HPV infection. The survival rates are poor due to di...


Biodentine™ Boosts, WhiteProRoot®MTA Increases and Life® Suppresses Odontoblast...

Paula, Anabela; Laranjo, Mafalda; Marto, Carlos Miguel; Abrantes, Ana Margarida; Casalta-Lopes, João; Gonçalves, Ana Cristina

(1) Background: When pulp exposure occurs, reparative dentinogenesis can be induced by direct pulp capping to maintain the vitality and function of the tissue. The aim of this work was to assess the cytotoxicity and bioactivity of three different direct pulp capping materials, calcium hydroxide (Life®), mineral trioxide aggregate (WhiteProRoot®MTA) and calcium silicate (Biodentine™), in an odontoblast-like mous...


Direct Pulp Capping: Which is the Most Effective Biomaterial? A Retrospective C...

Paula, Anabela; Carrilho, Eunice; Laranjo, Mafalda; Abrantes, Ana M.; Casalta-Lopes, João; Botelho, Maria Filomena; Marto, Carlos Miguel

(1) Background: Recently, tricalcium silicate cements, such as Biodentine™, have emerged. This biomaterial has a calcium hydroxide base and characteristics like mineral aggregate trioxide cements, but has tightening times that are substantially more suitable for their application and other clinical advantages. (2) Methods: A retrospective clinical study was conducted with 20 patients, which included a clinical ...


Synthetic Calcium Phosphate Ceramics as a Potential Treatment for Bisphosphonat...

Paulo, Siri; Laranjo, Mafalda; Abrantes, Ana M.; Casalta-Lopes, João; Santos, Kathleen; Gonçalves, Ana C.; Paula, Anabela Baptista; Marto, Carlos Miguel

(1) Background: Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is one of the most often seen side effects in patients treated with nitrogen-containing bisphosphonates (BPs), a post-surgical non-healing wound condition. Since calcium phosphate (CP) compounds are able to adsorb zoledronate (ZOL) when used as a drug delivery vehicle, we aimed to verify if these ceramics might have a potential protective e...


Doping β-TCP as a Strategy for Enhancing the Regenerative Potential of Composit...

Ferreira, Manuel M.; Brito, Ana F.; Brazete, Daniela; Pereira, Inês C.; Carrilho, Eunice; Abrantes, Ana M.; Pires, Ana S.; Aguiar, Maria J

The present work aims at evaluating the potential gains derived from partially replacing calcium in resorbable β-tricalcium phosphate (β-TCP) by two different molar percentages of strontium (5, 10) and zinc (1, 2), concomitantly with a fixed molar percentage (0.5) of manganese. Synthetic granular composite bone filling grafts consisting of doped β-TCP and an alkali-free bioactive glass were prepared and implant...


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