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How CYP2D6 Polymorphism Modulates the Community-Wide Risk of Plasmodium vivax I...

Puça, Maria Carolina Silva de Barros; Naziazeno, Isabela Marques; Santos, Viviane Cristina Fernandes dos; Rodrigues, Priscila Thihara

Background. The CYP2D6 enzyme plays a critical role in the metabolism of primaquine, the most widely used drug for the radical cure of Plasmodium vivax malaria. Impaired CYP2D6 activity has been associated with an increased risk of relapse. However, the overall impact of CYP2D6 on infection dynamics is still not fully understood. We hypothesized that individuals with impaired CYP2D6 activity develop partial imm...

Data: 2025 | Origem: Repositório Institucional da UNL

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Mining and malaria in the Brazilian Amazon and in the Yanomami indigenous land

Castro, Marcia C.; Arisco, Nicholas J.; Diniz, Cesar Guerreiro; Ponmattam, Jamie; Peterka, Cassio; Basta, Paulo Cesar; Ferreira, Marcelo Urbano

Illegal mining expanded in the Brazilian Amazon since 2018, leading to increases in malaria among indigenous populations, particularly the Yanomami. We describe the temporal and spatial pattern of malaria and mining in indigenous lands and quantify the impact of mining on malaria among the Yanomami. We estimate that a 1% increase in the annual mining area was associated with a 24% (95% CrI: 17%, 32%) increase i...

Data: 2025 | Origem: Repositório Institucional da UNL

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