11 documents found, page 1 of 2
Redefining ovarian cancer treatment with a first-in-class inhibitor of homologo...
Saraiva, Lucília H.; Pardal de Matos, Ana C.; Mota, Inês; Moura, Sara; Ciucci, Alessandra; Aguiar, Tatiana Quinta; Ricardo, Sara; Almeida, Maria I.Background: High-grade serous ovarian cancer (HGSOC) is characterized by poor prognosis and low overall survival. While PARP inhibitors (PARPis) are standard maintenance therapy for BRCA-mutated HGSOC (10% of cases), acquired resis-tance develops in over 60% of patients. We identied BBIT20, a rst-in-class inhibitor of the BRCA1-BARD1 interaction that disrupts homologous recombination (HR) DNA repair. Methods: B...
Comparative analysis of antioxidant and fatty acid composition in avocado (Pers...
Gonçalves, David; Gouveia, Carla S. S.; Ferreira, Maria J.; Ganança, José F. T.; Pinto, Diana C. G.; Carvalho, Miguel A. A. Pinheiro dehytochemical and biochemical properties. Aiming to evaluate the antioxidant quality and fatty acid composi tion with a commercial avocado, flours were obtained from five varieties (four regional and one commercial Hass) across different tissues (pulp and by-products) and cycles (years and on-tree maturation stages). Results showed that a regional variety with thin purple skin had the highest antioxidant qualiti...
The mammalian peroxisomal membrane is permeable to both GSH and GSSG - Implicat...
Ferreira, Maria J.; Rodrigues, Tony A.; Pedrosa, Ana G.; Gales, Luís; Salvador, Armindo; Francisco, Tânia; Azevedo, Jorge E.Despite the large amounts of H2O2 generated in mammalian peroxisomes, cysteine residues of intraperoxisomal proteins are maintained in a reduced state. The biochemistry behind this phenomenon remains unexplored, and simple questions such as "is the peroxisomal membrane permeable to glutathione?" or "is there a thiol-disulfide oxidoreductase in the organelle matrix?" still have no answer. We used a cell-free in ...
The root microbiome of Salicornia ramosissima as a seedbank for plant-growth pr...
Ferreira, Maria J.; Cunha, Angela; Figueiredo, Sandro; Faustino, Pedro; Patinha, Carla; Silva, Helena; Sierra-Garcia, Isabel N.Root−associated microbial communities play important roles in the process of adaptation of plant hosts to environment stressors, and in this perspective, the microbiome of halophytes represents a valuable model for understanding the contribution of microorganisms to plant tolerance to salt. Although considered as the most promising halophyte candidate to crop cultivation, Salicornia ramosissima is one of the le...
Siderophore-producing rhizobacteria as a promising tool for empowering plants t...
Ferreira, Maria J.; Silva, Helena; Cunha, ÂngelaIron (Fe) bioavailability to plants is reduced in saline soils; however, the exact mechanisms underlying this effect are not yet completely understood. Siderophore-expressing rhizobacteria may represent a promising alternative to chemical fertilizers by simultaneously tackling salt-stress effects and Fe limitation in saline soils. In addition to draught, plants growing in arid soils face two other major challen...
Control of crystallite and particle size in the synthesis of layered double hyd...
Galvão, Tiago L. P.; Neves, Cristina S.; Caetano, Ana P. F.; Maia, Frederico; Mata, Diogo; Malheiro, Eliana; Ferreira, Maria J.; Bastos, Alexandre C.Zinc–aluminum layered double hydroxides with nitrate intercalated (Zn(n)Al–NO3, n = Zn/Al) is an intermediate material for the intercalation of different functional molecules used in a wide range of industrial applications. The synthesis of Zn(2)Al–NO3 was investigated considering the time and temperature of hydrothermal treatment. By examining the crystallite size in two different directions, hydrodynamic part...
Control of crystallite and particle size in the synthesis of layered double hyd...
Galvão, Tiago L. P.; Neves, Cristina S.; Caetano, Ana P. F.; Maia, Frederico; Mata, Diogo; Malheiro, Eliana; Ferreira, Maria J.; Bastos, Alexandre C.Zinc-aluminum layered double hydroxides with nitrate intercalated (Zn(n)Al-NO3, n = Zn/Al) is an intermediate material for the intercalation of different functional molecules used in a wide range of industrial applications. The synthesis of Zn(2)Al-NO3 was investigated considering the time and temperature of hydrothermal treatment. By examining the crystallite size in two different directions, hydrodynamic part...
Preparation of crystal-like periodic mesoporous phenylene-silica derivatized wi...
Gomes, Ana C.; Ferreira, Maria J.; Bruno, Sofia M.; Bion, Nicolas; Ferreira, Paula; Valente, Anabela A.; Pillinger, Martyn; Rocha, JoaoThe surface silanol groups in crystal-like mesoporous phenylene-silica have been derivatized with trimethylsilyl, benzyldimethylsilyl and dimethylsilyl(ferrocene) groups by performing a post-synthetic grafting reaction with the corresponding chlorosilane precursors. The success of the grafting procedure was demonstrated by transmission FT-IR spectroscopy and diffuse reflectance infrared Fourier transform spectr...
Características psicométricas de uma versão portuguesa do "Competitive State An...
Cruz, José Fernando A.; Viveiros, Isabel; Alves, Luís A.; Gomes, António Rui; Matos, Daniela; Ferreira, Maria J.; Dias, Cláudia S.Para analisar as características psicométricas do "Competitive State Anxiety Inventory-2" (medida multidimensional do estado de ansiedade competitiva, com 27 itens), uma versão portuguesa foi administrada a 157 atletas de 5 modalidades (antes e depois da competição). Os dados obtidos sugerem uma estrutura de 3 factores idêntica à original, mas com a redução para 22 itens. Foram obtidos bons índices de fidelidad...
The suitability for organic cattle beef production of mixed farming systems in ...
Pires, Jaime; Rodrigues, M.A.; Sousa, Fernando Ruivo de; Bernardo, Adelino; Pires, João; Cabanas, J.E.; Resendes, Hugo; Ferreira, Maria J.The EC Reg. 1804/99 takes account of animal production in organic farming. However, these specifications may limit implementation and expansion of organic animal production, due to environmental and system constraints. Mixed farming, as defined by Spedding (1988) and Grigg (1996), is commonly practiced in the NE highlands of Portugal. Two farms were studied in this region in order to evaluate their suitability ...