8 documents found, page 1 of 1
The relationships between reading fluency and different measures of holistic wo...
Ventura, Paulo; Tse, Helen W.-Y.; Guerreiro, José Carlos; Delgado, João; Ferreira, Miguel F.; Farinha-Fernandes, António; Faustino, BrunoRecently, paradigms in the face recognition literature have been adopted to reveal holistic processing in word recognition. It is unknown, however, whether different measures of holistic word processing share similar underlying mechanisms, and whether fluent word reading relies on holistic word processing. We measured holistic processing effects in three paradigms (composite, configural sensitivity, part–whole)...
Sound symbolism is modulated by linguistic experience
Delgado, João; Pereira, Rodrigo; Ferreira, Miguel F.; Farinha-Fernandes, António; Guerreiro, José C.; Faustino, Bruno; Domingues, Miguel; Ventura, PauloThe bouba-kiki effect, or the symbolic association between certain speech sounds and rounded or angular shapes, is widely thought to be universal. However, two studies have failed to replicate this effect with neurotypical participants in the classical paradigm, one conducted in Papua New Guinea (Ross & Rogers, 1975), and the other conducted in Nepal (Styles & Gawne, 2017). As both experiments employed ...
Sound symbolism is modulated by linguistic experience
Delgado, João; Pereira, Rodrigo; Ferreira, Miguel F.; Farinha-Fernandes, António; Guerreiro, José Carlos; Faustino, Bruno; Domingues, MiguelThe bouba-kiki effect, or the symbolic association between certain speech sounds and rounded or angular shapes, is widely thought to be universal. However, two studies have failed to replicate this effect with neurotypical participants in the classical paradigm, one conducted in Papua New Guinea (Ross & Rogers, 1975), and the other conducted in Nepal (Styles & Gawne, 2017). As both experiments employed auditory...
Holistic word processing is correlated with efficiency in visual word recognition
Ventura, Paulo; Fernandes, Tânia; Pereira, Alexandre; Guerreiro, José Carlos; Farinha-Fernandes, António; Delgado, João; Ferreira, Miguel F.Holistic processing of visual words (i.e., obligatory encoding of/attending to all letters of a word) could be a marker of expert word recognition. In the present study, we thus examined for the first time whether there is a direct relation between the wordcomposite effect (i.e., all parts of a visual word are fully processed when observers perform a task on a word part) and fast access to the orthographic lexi...
Cannabinoid actions on neural stem cells: implications for pathophysiology
Rodrigues, Rui S.; Lourenço, Diogo M.; Paulo, Sara L; Mateus, Joana; Ferreira, Miguel F.; Mouro, Francisco; Moreira, João B.; Ribeiro, FilipaWith the increase of life expectancy, neurodegenerative disorders are becoming not only a health but also a social burden worldwide. However, due to the multitude of pathophysiological disease states, current treatments fail to meet the desired outcomes. Therefore, there is a need for new therapeutic strategies focusing on more integrated, personalized and effective approaches. The prospect of using neural stem...
Gold nanoparticles functionalised with fast water exchanging Gd3+ chelates: Lin...
Martins, J. A. R.; Ferreira, Paula M. T.; Geraldes, Carlos F. G. C.; Helm, Lothar; Prata, Maria I. M.; Rodrigues, Sérgio P. J.; Rodrigues, Tiago B.The relaxivity displayed by Gd3+ chelates immobilized onto gold nanoparticles is the result of complex interplay between nanoparticle size, water exchange rate and chelate structure. In this work we study the effect of the length of -thioalkyl linkers, anchoring fast water exchanging Gd3+ chelates onto gold nanoparticles, on the relaxivity of the immobilized chelates. Gold nanoparticles functionalized with Gd3...
Ga[NO2A-N-(alfa-amino)propionate] chelates: synthesis and evaluation as potenti...
Ferreira, Miguel F.; Pereira, Goreti; André, João P.; Prata, M. I. M.; Ferreira, Paula M. T.; Martins, José A.; Geraldes, Carlos F. G. C.The availability of commercial 68Ge/68Ga cyclotron-independent 68Ga3+ generators is making Positron Emission Tomography (PET) accessible to most hospitals, which is generating a surge of interest in the design and synthesis of bi-functional chelators for Ga3+. In this work we introduce the NO2A-N-(alfa-amino)propionic acid family of chelators based on the triazacyclononane scaffold. Complexation of the parent N...
Ln[DO3A-N-alfa-(pyrenebutanamido)propionate] complexes : optimized relaxivity a...
Ferreira, Miguel F.; Pereira, Goreti; Martins, A. F.; Martins, Catarina I. O.; Prata, M. I. M.; Petoud, S.; Toth, E.; Ferreira, Paula M. T.We have proposed recently that the DO3A-N-alfa-(amino)propionate chelator and its amide conjugates are leads to targeted, high relaxivity, safe Contrast Agents for Magnetic Resonance Imaging. In this work we illustrate further the expeditious nature and robustness of the synthetic methodologies developed by preparing the DO3A-N-(alfa-pyrenebutanamido)propionate chelator. Its Gd3+ chelate retains the optimized w...