8 documents found, page 1 of 1
Modulation of Leptin and Leptin Receptor Expression in Mice Acutely Infected wi...
Teixeira, L; Correia, A; Oliveira, BM; Pinto, A; Ferreira, PG; Manuel VilanovaNeospora caninumis an apicomplexan parasite that in cattle assumes particular importance, as it is responsible for abortions reported worldwide. Leptin is an adipokine mainly secreted by adipocytes, which beside its role in maintaining metabolic homeostasis also has important effects in both innate and adaptive immunity. In previous work, we showed that mice chronically infected withN. caninumhad elevated serum...
Gender Differential Transcriptome in Gastric and Thyroid Cancers
Sousa, A; Ferreira, M; Oliveira, C; Ferreira, PGCancer has an important and considerable gender differential susceptibility confirmed by several epidemiological studies. Gastric (GC) and thyroid cancer (TC) are examples of malignancies with a higher incidence in males and females, respectively. Beyond environmental predisposing factors, it is expected that gender-specific gene deregulation contributes to this differential incidence. We performed a detailed c...
Characterization of Myeloid Cellular Populations in Mesenteric and Subcutaneous...
Oliveira, BM; Pinto, A; Correia, A; Ferreira, PG; Manuel Vilanova; Teixeira, LImmune cells resident in adipose tissue have important functions in local and systemic metabolic homeostasis. Nevertheless, these immune cell populations remain poorly characterized in bovines. Recently, we described diverse lymphocyte subpopulations in adipose tissue of Holstein-Friesian cows. Here, we aimed at characterising myeloid cell populations present in bovine adipose tissue using multicolour flow cyto...
Integrated Analysis of Structural Variation and RNA Expression of FGFR2 and Its...
Teles, SP; Oliveira, P; Ferreira, M; Carvalho, J; Ferreira, PG; Oliveira, CGastric Cancer (GC) is one of the most common and deadliest types of cancer in the world. To improve GC prognosis, increasing efforts are being made to develop new targeted therapies. Although FGFR2 genetic amplification and protein overexpression in GC have been targeted in clinical trials, so far no improvement in patient overall survival has been found. To address this issue, we studied genetic and epigeneti...
The effects of death and post-mortem cold ischemia on human tissue transcriptomes
Ferreira, PG; Muñoz-Aguirre, M; Reverter, F; Sá Godinho, C; Sousa, A; Amadoz, A; Sodaei, R; Hidalgo, M; Pervouchine, D; Carbonell-Caballero, JPost-mortem tissues samples are a key resource for investigating patterns of gene expression. However, the processes triggered by death and the post-mortem interval (PMI) can significantly alter physiologically normal RNA levels. We investigate the impact of PMI on gene expression using data from multiple tissues of post-mortem donors obtained from the GTEx project. We find that many genes change expression ove...
A novel immunodeficiency syndrome as a rare cause of secondary pulmonary alveol...
Ferreira, PG; Carvalho, L; Gamboa, FCase report of a male patient with a five-decade follow-up history in a tertiary care hospital distinguished for malabsorption syndrome, failure-to-thrive, meningitis and recurrent bacterial, fungal and mycobacterial pulmonary infections. Additionally, he developed epidermodysplasia verruciformis, several in situ spinocellular carcinomas and an uncharacteristic parenchymal lung disease. Surgical lung biopsy sug...
Urinothorax as an unusual type of pleural effusion - Clinical report and revisi...
Ferreira, PG; Furriel, F; Ferreira, AJBACKGROUND: Despite the fact that there are a great number of established etiologies for pleural effusion, there are grounds for believing that there are also causes from unusual pathophysiological mechanisms, seen in certain clinical contexts and from potential iatrogenic interventions. Urinothorax is such a rare type of pleural effusion as there are fewer than 70 cases reported worldwide. CLINICAL CASE: A pat...
Acute onset pulmonary toxicity associated to amiodarone
Ferreira, PG; Saraiva, F; Carreira, CAmiodarone is a potent anti-arrhythmic drug with a well-known potential chronic pulmonary toxicity. We describe a case of acute pulmonary toxicity (APT) induced by amiodarone in a 57 year old patient submitted to a perfusion of 900 mg in just 6 hours, to control an auricular flutter with rapid ventricular response. During the administration, the patient developed hemodynamic instability and oxygen dessaturation...