140 documents found, page 1 of 14
N-Succinylated canonical vs. dehydropeptides: contrasting self-assembly pathway...
Pereira, Teresa; Carvalho, André F.; Teixeira, Filipe; Magalhães, Andreia Patrícia; Pereira, David M.; Hilliou, L.; Abrunhosa, AnteroLimited mechanical robustness and prompt proteolytic degradation preclude wider biomedical application of supramolecular peptide hydrogels. Low-molecular-weight dehydropeptides represent a promising class of hydrogelators, owing to their enhanced proteolytic stability, high self-assembly propensity, biocompatibility, and tunable rheological and drug-release properties. Herein, we prepared a small library of N-s...
Structure–property relationships in symmetrical bolaamphiphilic dehydrodipeptid...
Amorim, Carolina; Carvalho, André Filipe Gonçalves de; Figueiredo, Pedro R.; Carvalho, Alexandra T. P.; Hilliou, L.; Pereira, David M.Peptide-based supramolecular hydrogels have emerged as promising biomaterials due to inherent biocompatibility, tunable self-assembly, and structural similarity to the extracellular matrix. This work describes the design, synthesis and characterization of a library of symmetrical bolaamphiphiles based on dehydropeptides, systematically varying both the dehydroamino acid residue and the linker. Aromatic and alip...
Poly(L-Tyrosine)-Containing Dehydropeptides: Hydrogels vs. Bioadhesives
Dias, Ana; Hilliou, L.; Uribe, Braian Esneider Buitrago; Martins, J. A. R.; Ferreira, Paula M. T.Bioadhesive materials capable of operating under aqueous conditions are of considerable interest for biomedical and materials science applications. Peptide-based systems represent an attractive platform for such materials due to their structural tunability, inherent biocompatibility, and ability to form supramolecular networks through noncovalent interactions. In this work, a focused library of tyrosine-contain...
Multifunctional magneto-plasmonic lipogel based on peptide hydrogel for applica...
Gomes, Valéria; Veloso, Sérgio R. S.; Carvalho, André; Hilliou, L.; Coutinho, Paulo J. G.; Moura, C.; Martins, J. A. R.; Castanheira, Elisabete M. S.Supramolecular hydrogels, particularly low-molecular-weight peptide hydrogels, are promising drug delivery systems due to their ability to change the solubility, targeting, metabolism and toxicity of drugs. Magneto-plasmonic liposomes, in addition to being remotely controllable with the application of an external magnetic field, also increase the efficiency of encapsulated drug release through thermal stimulati...
Tripeptides featuring dehydrophenylalanine and homophenylalanine: homo- versus ...
Carvalho, André F.; Pereira, Teresa; Oliveira, Carlos; Figueiredo, Pedro; Carvalho, Alexandra; Pereira, David M.; Hilliou, L.; Bañobre-López, ManuelOver the years, our research group developed dehydrodipeptides N-capped with aromatic moieties as protease-resistant efficacious hydrogelators, affording self-assembled hydrogels at low (critical) concentrations. Dehydrotripeptides, with different dipeptide sequences and (D,L) stereochemistry, open a wider chemical space for the development of self-assembled soft nanomaterials. In this work, a small library of ...
Self-assembly pathway influence on Dehydropeptide-based gel properties and drug...
Veloso, Sérgio R S; Vijayakanth, Thangavel; Shankar, Sudha; Fridman, Natalia; Rencus-Lazar, Sigal; Hilliou, L.; Rodrigues, Pedro V.; Moura, C.Low-molecular-weight peptide-based hydrogels formed through self-assembly have emerged as promising candidates for biomedical applications. While the self-assembly process is known to affect the network morphology, its impact on mechanical properties and drug delivery remains poorly understood. In this work, it is explored how different gelation conditions influence the morphology, properties, and drug release ...
New supramolecular hydrogels based on diastereomeric dehydrotripeptide mixtures...
Oliveira, Carlos B. P.; Carvalho, André; Pereira, Renato B.; Pereira, David M.; Hilliou, L.; Jervis, Peter J.; Martins, J. A. R.; Ferreira, Paula M. T.Self-assembly of peptide building blocks offers unique opportunities for bottom-up preparation of exquisite nanostructures, nanoarchitectures, and nanostructured bulk materials, namely hydrogels. In this work we describe the synthesis, characterization, gelation, and rheological properties of new dehydrotripeptides, Cbz-L-Lys(Cbz)-L,D-Asp-∆Phe-OH and (2-Naph)-L-Lys(2-Naph)-L,D-Asp-∆Phe-OH, containing a N-termin...
An injectable composite co‐assembled dehydropeptide‐based magnetic/plasmonic li...
Veloso, Sérgio R. S.; Vázquez‐González, Margarita; Spuch, Carlos; Freiría‐Martínez, Luis; Comís‐Tuche, María; Iglesias‐Martínez‐Almeida, MartaAdvancing therapeutic effectiveness through the strategic co-delivery of drugs in a sequential manner represents a compelling strategy. However, achieving precise and selective release of chemotherapeutic agents remains a formidable challenge. In this study, a co-assembled Arginine-Glycine-Aspartate (RGD)-functionalized dehydropeptide-based gel loaded with magnetic liposomes and mesoporous silica-coated gold na...
Unveiling the role of capping groups in naphthalene N-capped dehydrodipeptide h...
Vilaça, Helena; Carvalho, André; Castro, Tarsila Gabriel; Castanheira, Elisabete M. S.; Hilliou, L.; Hamley, Ian; Melle-Franco, ManuelSelf-assembled peptide-based hydrogels are archetypical nanostructured materials with a plethora of foreseeable applications in nanomedicine and as biomaterials. N-protected di- and tri-peptides are effective minimalist (molecular) hydrogelators. Independent variation of the capping group, peptide sequence and side chain modifications allows a wide chemical space to be explored and hydrogel properties to be tun...
Fisetin derivatives exhibit enhanced anti-inflammatory activity and modulation ...
Silva, Daniela Correia da; Jervis, Peter John; Martins, J. A. R.; Valentão, Patrícia; Ferreira, Paula M. T.; Pereira, David M.Fisetin (FST) is a dietary flavonol that is known to possess multiple relevant bioactivities, raising the question of its potential health benefits and even its use in novel pharmacological approaches. To attain this prospect, some limitations to this molecule, namely its poor bioavailability and solubility, must be addressed. Inflammation and endoplasmic reticulum (ER) stress are often hand in hand in the cont...