28 documents found, page 1 of 3
Food products based on Cannabis extract: from “Brisadeiro” to searching for a t...
Delmiro, Josué de Araújo; Torres, Francisco Brenon de Oliveira; Almeida, Antonia Amanda Cardoso de; Ferreira, Paulo Michel PinheiroIntroduction. Cannabis-based edibles have become a lucrative and in-demand market. Despite not being legalized in Brazil, marijuana is found in oral preparations illegally marketed in the country and the search for these products has grown in recent years. The present study aims to gather data from the scientific literature on the physiology of the endocannabinoid system, effects of oral cannabis consumption, p...
Estudos pré-clínicos da atividade antiproliferativa e toxicológica da fração e ...
Ferreira, Paulo Michel PinheiroAmong all antitumor molecules available between 1940 and 2002, 40 % has natural origin. However, most of the clinically used antineoplasic compounds lead to adverse effects due to a therapeutic narrow window, pharmacological multiple resistance and morphological and physiological similarities between transformed and normal cells. Given this requirement for the developing of new anticancer drugs, it was initiall...
Biopolymer from water kefir as a potential clean-label ingredient for health ap...
Lucena, Monalisa de Alencar; Ramos, Igor Frederico da Silveira; Geronço, Maurycyo Silva; Araújo, Ricardo de; Filho, Francisco Lopes da SilvaThe present work aimed to characterize the exopolysaccharide obtained from water kefir grains (EPSwk), a symbiotic association of probiotic microorganisms. New findings of the technological, mechanical, and biological properties of the sample were studied. The EPSwk polymer presented an Mw of 6.35 x 10(5) Da. The biopolymer also showed microcrystalline structure and characteristic thermal stability with maximum...
Infraspecific Chemical Variability and Biological Activity of Casearia sylvestr...
Bueno, Paula Carolina Pires [UNESP]; Abarca, Luis Francisco Salomé; Anhesine, Naira Buzzo [UNESP]; Giffoni, Maíra Silva [UNESP]Made available in DSpace on 2021-06-25T10:47:52Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-02-01; Casearia sylvestris is an outstanding representative of the Casearia genus. This representability comes from its distinctive chemical profile and pharmacological properties. This species is widespread from North to South America, occurring in all Brazilian biomes. Based on their morphology, 2 varieties ...
Phenolic derivatives and antioxidant activity of polar extracts from Bauhinia p...
Carvalho, Adonias Almeida; Santos, Lucivania Rodrigues dos; Farias, Ruth Raquel Soares de; Chaves, Mariana Helena; Feitosa, Chistiane MendesA tea made with the leaves or stem bark of Bauhinia pulchella Benth (Fabaceae) is used in the treatment of diabetes. Ethanol (EEF) and aqueous (EAF) extracts were obtained from the leaves and the antioxidant and citotoxic activities were tested, as well as quantify the content of flavonoids and phenolic compounds (TPC). EEF and EAF showed similar profiles by HPLC, with the presence of three compounds. Column ch...
Molecular biology of human epidermal receptors, signaling pathways and targeted...
Ferreira, Paulo Michel Pinheiro; Pessoa, CláudiaHuman epidermal receptors (HER1/2/3/4) belong to the class of receptor-type tyrosine kinases. After binding a ligand, dimerization, it will ocurr activation of intracellular kinases after two-dimensional and cytoplasmic tail reciprocal transphosphorylation. This transphosphorylation recruits signaling pathways such as Ras/Raf/MEK/Erk1-2, PI3-K/AKT and JAK/STAT, which can affect the cell cycle, cytoskeleton reor...
Biomedical properties and potentiality of Lippia microphylla Cham. and its esse...
Simões, Evelyne Rolim Braun; Santos, Evelyne Alves; Abreu, Maria Carolina de; Silva, Jurandy do Nascimento; Nunes, Nárcia Mariana FonsecaLippia microphylla Cham. (Verbanaceae) is an endemic underexploited Brazilian vegetal. This work reviewed the biological potentialities of Lippia microphylla, emphasizing the properties of essential oils (EOs) and analyzed scientific indicators about genus Lippia and L. microphylla. Databases from 1948 to the present were searched and a software (Vantage Point 7.1) associated with Derwent Innovation Index was u...
Counteracting effects on free radicals and histological alterations induced by ...
Araújo, Éverton José Ferreira de; Oliveira, Guilherme Antônio Lopes de; Sousa, Lívia Queiroz de; Bolzani, Vanderlan da Silva; Cavalheiro, Alberto JoséCasearia sylvestris Swartz is a medicinal plant widely distributed in Brazil. It has anti-inflammatory, antiulcer and antitumor activities and is popularly used to treat snakebites, wounds, diarrhea, flu and chest colds. Its leaves are rich in oxygenated tricyclic cis -clerodane diterpenes, particulary casearins. Herein, we evaluated the antioxidant activities of a fraction with casearins (FC) isolated from C. ...
Toxicogenetic profile of rats treated with aqueous extract from Morinda citrifo...
Moraes, Germano Pinho de; Alencar, Marcus Vinícius Oliveira Barros de; Islam, Torequl; Araújo, Lidiane da Silva; Gomes, Débora Cássia VieiraMorinda citrifolia ( (Family: Rubiaceae) ) is extensive ly use d in traditional med icine due to its anti - inflammatory, antimicrobial, antitumoral , and anti - hypertensive act ivities . However, t here is no substantial data about hepatotoxic and toxicogenetic effects . This study evaluated bioch emical changes and hepatotoxic, genotoxic , and mu tagenic effects of aqueous extract of the fruit of M. citrifol...
Preparation of phytol-loaded nanoemulsion and screening for antioxidant capacity
Islam, Torequl; Streck, Leticia; Paz, Márcia Fernanda Correia Jardim; Sousa, João Marcelo de Castro e; Alencar, Marcus Vinícius Oliveira Barros deThe study prepared a nanoemulsion with a diterpenoid isoprenoid alcohol called phytol (PYT) and subsequently tested it for antioxidant capacity. For this, PYT-loaded nanoemulsion was prepared by phase inversion method and both PYT-containing nanoemulsion (PNE) and PYT-free nanoemulsion (PFNE) (2-16 µM) were tested for antiradical activity (DPPH•: 1,1-dipheny-picrylhydrazyl radical; ABTS•+: azino-bisethylbenzthi...