190 documents found, page 1 of 19
Programmes Addressed to Informal Caregivers’ Needs: A Systematic Literature Rev...
Gemito, L; Alves, Elisabete; Moreira, J; Marques, MF; Caldeira, E; Ferreira, R; Bico, I; Pinho, L; Fonseca, C; Sousa, L; Lopes, MBackground: Addressing informal caregivers' needs is essential for ensuring quality healthcare and promoting citizen-centred care. This systematic review assessed current knowledge about programmes aimed at meeting the needs of informal caregivers of adults who are dependent on others for daily life activities. Methods: Following the PRISMA guidelines, the electronic databases EBSCOhost Research Platform, MEDLI...
Depression, Loneliness and Quality of Life in Institutionalised and Non-Institu...
Silva, C; Ferreira, R; Morgado, B; Alves, Elisabete; Fonseca, CésarOur study aims to estimate the prevalence of depressive symptomatology among older adults and to assess their association with loneliness and quality of life according to institutionalisation status in a Portuguese sample. Background: The World Health Organisation estimates that by 2050, the world’s population over 60 will number two billion people, which poses complex challenges in terms of maintaining the men...
Exploring Sustainable Fertilization Strategies Involving Biochar, Compost, and ...
Machado, R.M.A.; Alves-Pereira, I; Velez, D; Grilo, A; Veríssimo, I; Ferreira, RThe effect of fertilization strategies involving biochar, compost, and inorganic N on growth and phytochemical accumulation in turnips was studied in a greenhouse pot experiment. The experiment was carried out with six fertilizer treatments: unfertilized soil (US), compost (120 g/pot) + biochar (20 g/pot) (C + B), compost (120 g/pot) + 0.5 g N/pot (C + 0.5 N), biochar (20 g/pot) + 0.5 g N/pot (B + 0.5 N), compo...
Comprehensive histopathological analysis of gastric cancer in European and Lati...
Martínez-Ciarpaglini, C; Barros, R; Caballero, C; Boggino, H; Alarcón-Molero, L; Peleteiro, B; Ruiz-García, E; Fernandez-Figueroa, E"Introduction: Gastric cancer (GC) burden is currently evolving with regional differences associated with complex behavioural, environmental, and genetic risk factors. The LEGACy study is a Horizon 2020-funded multi-institutional research project conducted prospectively to provide comprehensive data on the tumour biological characteristics of gastroesophageal cancer from European and LATAM countries. Material a...
Pharmacological NF-κB inhibition decreases cisplatin chemoresistance in muscle-...
Gil da Costa, Rui; Levesque, C; Bianchi-Frias D; Chatterjee, P; Lam, HM; Santos, C; Coleman, IM; Ferreirinha, P; Vilanova, M; Pinto da Cunha, NMost patients with muscle-invasive bladder cancer (MIBC) are not cured with platinum chemotherapy. Up-regulation of nuclear factor kappa light-chain enhancer of activated B cells (NF-κB) is a major mechanism underlying chemoresistance, suggesting that its pharmacological inhibition may increase platinum efficacy. NF-κB signaling was investigated in two patient cohorts. The Cancer Genome Atlas (TCGA) was used to...
Appraising animal models of prostate cancer for translational research: future ...
Nascimento-Gonçalves, E; Seixas, F; Gil da Costa, R; Pires, MJ; Neuparth, MJ; Moreira-Gonçalves, D; Fardilha, M; Faustino-Rocha, Ana I; Colaço, BThe growing incidence of prostate cancer has prompted a great investment in basic biology and translational studies to develop new therapies. Multiple animal models have been established to study etiological factors, cancer-preventive strategies and the molecular determinants of aggressiveness and metastases. The rat model of prostate cancer induced by chemical carcinogen N-methyl-N-nitrosourea (MNU) and testos...
The impact of resveratrol-enriched bread on cardiac remodeling in a preclinical...
Silva, AFR; Silva-Reis, R; Ferreira, R; Oliveira, Paula A; Faustino-Rocha, Ana I; Pinto, ML; Coimbra, MA; Silva, AMS; Cardoso, SAbstract The World Health Organization aims to stop the rise of diabetes by 2025, and diet is one of the most efficient non-pharmacological strategies used to prevent it. Resveratrol (RSV) is a natural compound with anti-diabetic properties, and incorporating it into bread is a suitable way to make it more accessible to consumers as it can be included as part of their daily diet. This study aimed to evaluate th...
Lifelong exercise training promotes the remodelling of the immune system and pr...
Nascimento-Gonçalves, E; Seixas, F; Palmeira, C; Martins, G; Duarte, JA; Faustino-Rocha, Ana I; Colaço, B; Pires, MJ; Neuparth, MJ; Moreira-Gonçalves, DThis work aimed to understand how lifelong exercise training promotes the remodelling of the immune system and prostate signalome in a rat model of PCa. Fifty-five male Wistar rats were divided into four groups: control sedentary, control exercised, induced PCa sedentary and induced PCa exercised. Exercised animals were trained in a treadmill for 53 weeks. Pca induction consisted on the sequential administratio...
Studying and analyzing humane endpoints in the fructose-fed and streptozotocin-...
Silva-Reis, R; Faustino-Rocha, Ana I; Silva, J; Valada, A; Azevedo, T; Anjos, L; Gonçalves, L; Pinto, ML; Ferreira, R; Silva, AM; Cardoso, SMThis study assessed a humane endpoint scoring system to detect animal suffering in a rat model of type 2 diabetes. Sprague-Dawley male rats were divided into control and induced (fructose-fed and streptozotocin (STZ) administration) groups. Induced animals drank 10% fructose for 14 days, then received STZ (40 mg/kg) intraperitoneally. Weekly monitoring of body weight, water, and food consumption, 14 parameters ...
Moderate intensity treadmill exercise influences the immune system and prostate...
Nascimento-Gonçalves, E; Seixas, F; Palmeira, C; Martins, G; Fonseca, C; Duarte, JA; Faustino-Rocha, Ana I; Colaço, B; Pires, MJ; Neuparth, MJMaterial & Methods: Fifty-five male Wistar rats were divided into: control sedentary (SED+CONT; n=10), control exercised (EX+CONT; n=10), induced sedentary (SED+PCa; n=15), and induced exercised (EX+PCa; n=20). Exercised animals were trained in a treadmill, for 53 weeks. PCa induction consisted of flutamide and N-methyl-N-nitrosourea administration, followed by testosterone propionate implants. At sacrifice, pr...