A detenção e a criação de animais em explorações caseiras podem representar um risco para a transmissão de agentes patogénicos zoonóticos e de genes de resistência a antibióticos, com impacto na saúde pública. Em Portugal, a ausência de registo de sistemas de produção caseira (SPC) dificulta a caracterização das práticas de gestão e criação de animais, assim como o perfil dos seus proprietários. Este estudo pil...
This study aimed to investigate the impact of a Western diet and resistance training on cardiac remodeling in a rat model of chemically induced mammary cancer. Fifty-six female Wistar rats were randomly assigned to one of eight experimental groups, evaluating the impact of Western and standard diets, exercise and sedentarism, and the induction of mammary cancer. Mammary cancer was induced via the intraperitonea...
Breast cancer remains a significant global health issue, affecting both humans and companion animals, particularly female dogs and cats, where mammary tumors are among the most common cancers. Strategies to minimize the impact of this disease on patients, pet owners, and veterinary medicine are essential. This study analyses the effects of resistance training on the development of chemically induced mammary can...
INTRODUCTION: Arteriovenous Malformations (AVMs) are high-fow anomalous connections between the arterial and venous systems composed of dysplastic vessels resulting from aberrant angiogenesis. They are congenital and when symptomatic they rarely manifest before adolescence. Depending on the location, size, stage and severity of the symptoms, treatment options vary from conservative management to surgical resect...
Background: Substantial improvements in survival have been observed in HER2 (human epidermal growth factor receptor 2)-positive (HER2+) inoperable or metastatic breast cancer (advanced breast cancer [ABC]) in recent years, driven by the introduction and widespread use of multiple novel agents. The DESTINY-Breast02 trial compared the efficacy and safety of trastuzumab deruxtecan (T-DXd) in patients with HER2+ AB...
Identifying biogeographical patterns and important biological (blue) corridors can greatly contribute to conservation planning. Yet, this is particularly challenging when addressing pelagic species. In this study, satellite telemetry and photographic-identification data of short-finned pilot whales (Globicephala macrorhynchus) were used to identify preferred areas and pathways in the Macaronesia biogeographical...
Em Portugal, tal como internacionalmente, as Perturbações da Aprendizagem Específicas (PAE) constituem uma realidade que afeta muitas crianças. O número de crianças com necessidades educativas especiais que encontramos nas nossas escolas situa-se entre 10 a 12%, sendo que metade destas crianças, 5 a 6%, apresentam características frequentemente associadas a PAE. A teoria evidencia que a identificação precoce de...
Ventricular septal rupture (VSR) after myocardial infarction (MI) is a rare but life-threatening complication. Although surgery is the gold standard treatment, best surgical timing is still a matter of debate. Studies are showing a tendency towards survival improvement with delayed intervention on the assumption that scarring of the infarcted tissue may facilitate patch suturing and avoid relapse of the defect....
Objectives: Chlamydia trachomatis is classified into 15 major genotypes, A to L3, based on the diversity of ompA gene. Here, we evaluated and characterised the distribution and diversity of ompA-genotypes over 32 years (1990–2021) in Portugal. Methods: The collection of the Portuguese National Reference Laboratory for Sexually Transmitted Infections includes 5824 C. trachomatis-positive samples that were succes...
Background: Lymphogranuloma venereum (LGV) is a sexually transmitted infection caused by Chlamydia trachomatis ompA-genotypes L1–L3, with increasing numbers of detected cases across Europe. Here, we analysed diversity and temporal distribution of the LGV ompA-subvariants detected in Portugal between 2007 and 2023, in order to better understand the dissemination and diversification landscape of LGV strains. Meth...