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Cellular effects of Titanium Dioxide Nanoparticles in the intestine
Rolo, Dora; Pereira, Joana F.S.; Matos, Paulo; Gonçalves, Lídia; Bettencourt, Ana Francisca; Jordan, Peter; Silva, Maria João; Louro, HenriquetaIntroduction: The increased use of titanium dioxide nanoparticles (TiO2-NPs) as a food additive demands a thorough assessment of their potential risk for human health. Via oral exposure they may lead to adverse local or systemic outcomes, and few studies have focused on the cellular internalization mechanisms (endocytosis) of TiO2-NPs. The objective was to analyze the mechanisms by which TiO2-NPs (NM-102, NM-10...
Titanium Dioxide Nanoparticles molecular effects: Internalization in the Human ...
Rolo, Dora; Pereira, Joana FS; Matos, Paulo; Gonçalves, Lídia; Bettencourt, Ana Francisca; Jordan, Peter; Silva, Maria João; Louro, HenriquetaThe use of titanium dioxide nanoparticles (TiO2-NPs) as food additive and in food packaging demands a thorough assessment of their potential risk for human health, specifically with regard to gastrointestinal tract. Using intestinal cells, we analyzed the mechanisms by which digested TiO2-NPs (NM-102, NM-103 and NM-105, JRC repository) translocate through the intestinal epithelium layer, as compared to non-dige...
Analysis Of The Cytotoxicity And Genotoxicity of Digested Titanium Dioxide Nano...
Louro, Henriqueta; Vieira, Adriana; Gramacho, Ana Catarina; Rolo, Dora; Vital, Nádia; Martins, Carla; Assunção, Ricardo; Alvito, Paula; Gonçalves, LídiaTitanium dioxide nanomaterials (TiO2) have been frequently applied as food additives, in pharmaceuticals and in personal care products, such as toothpastes. Despite some regulators like EFSA concluded that the absorption of orally administered TiO2 is low, and that the use of TiO2 as a food additive does not raise a genotoxic concern, the presence of TiO2 in human organs was recently reported. This exposure may...
Acrylic microparticles increase daptomycin intracellular and in vivo anti-biofi...
Woischnig, Anne Kathrin; Gonçalves, Lidia M.; Ferreira, Maxime; Kuehl, Richard; Kikhney, Judith; Moter, Annette; Ribeiro, Isabel A. C.Daptomycin (DAP) is a cyclic lipopeptide antibiotic with potential clinical application in orthopedic infections caused by staphylococci. However, it failed to eradicate Staphylococcus aureus in vitro, in intracellular infection studies, as well as in vivo in an experimental model of implant-associated biofilm infections. In this study, the antimicrobial effect of DAP encapsulated in poly(methyl methacrylate)-E...
Aprender a partir da interdisciplinaridade
Bettencourt, Ana Francisca; Lopes, Sílvia Costa; Ribeiro, Helena MargaridaO presente artigo tem por objetivo salientar a importância da articulação entre a utilização das tecnologias de informação e comunicação e a aprendizagem em diversas áreas e, em particular, nas Ciências Farmacêuticas. Assim, no âmbito de unidades curriculares opcionais da Licenciatura em Ciências da Saúde e do Mestrado Integrado em Ciências Farmacêuticas da Universidade de Lisboa, foi proposta a participação at...
Osteomyelitis: an overview of antimicrobial therapy
Gomes, Diana; Pereira, Margarida; Bettencourt, Ana FranciscaA osteomielite é um processo inflamatório do tecido ósseo, de origem infecciosa, que resulta em destruição inflamatória, necrose e formação de novo osso. Pode aparecer em qualquer idade, afetar qualquer osso e tornar-se uma doença crônica com morbidade persistente. Apesar dos progressos na quimioterapia infecciosa, o tratamento da osteomielite é caro e difícil, em particular quando associada à presença de biofi...