27 documents found, page 1 of 3
Right ventricular to pulmonary arterial uncoupling
Timóteo, Ana Teresa; Rosa, Silvia Aguiar; Branco, Luísa Moura; Galrinho, Ana; Rio, Pedro Santos; Thomas, Boban; Ferreira, Rui CruzAbstract: Right ventricular (RV) to pulmonary arterial (PA) uncoupling measures RV exhaustion. There is limited evidence regarding the association between RV to PA coupling and hypertrophic cardiomyopathy (HCM). Evaluate RV to PA uncoupling in patients with HCM. Prospective cohort study in 62 patients with HCM without obstructive epicardial coronary disease. Echocardiography was used to assess RV to PA coupling...
The contribution of genetics to the understanding and management of cardiomyopa...
Cardoso, Isabel; Nunes, Sofia; Brás, Pedro; Viegas, José Miguel; Marques Antunes, Miguel; Ferreira, André; Almeida, Inês; Custódio, InêsGenetics has assumed a pivotal role in clarifying the pathophysiology of cardiomyopathies, facilitating molecular diagnosis, and enabling effective family screening. The advent of next-generation sequencing has revolutionized genetic testing by enabling cost-effective, high-throughput analysis. It is imperative for cardiovascular physicians to mainstream genetic testing into their clinical decision-making. Alth...
The impact of atrial voltage and conduction velocity phenotypes on atrial fibri...
Cunha, Pedro; Laranjo, Sérgio; Monteiro, Sofia; Portugal, Guilherme; Guerra, Cátia; Rocha, António Condeixa; Pereira, Mariana; Ferreira, Rui CruzIntroduction: Low atrial voltage and slow conduction velocity (CV) have been associated with atrial fibrillation (AF); however, their interaction and relative importance as early disease markers remain incompletely understood. We aimed to elucidate the relationship between atrial voltage and CV using high-density electroanatomic (HDE) maps of patients with AF. Methods: HDE maps obtained during sinus rhythm in 5...
Very-early detection of atrial fibrillation after ablation evaluated by a weara...
Marques Antunes, Miguel; Cunha, Pedro; Lacerda Teixeira, Bárbara; Portugal, Guilherme; Valente, Bruno; Lousinha, Ana; Delgado, Ana Sofia; Alves, SandraIntroduction: Atrial fibrillation (AF) ablation represents a safe and effective procedure to restore sinus rhythm. The idea that post-procedural AF episodes - during the blanking period - are not considered treatment failure has been increasingly challenged. The E-Patch, a single-use adhesive electrode, facilitates extended continuous ECG monitoring for 120 h. This pilot study aims to assess the effectiveness o...
Epicardial adipose tissue volume assessed by cardiac CT as a predictor of atria...
Teixeira, Bárbara Lacerda; Cunha, Pedro; Jacinto, Ana Sofia; Portugal, Guilherme; Laranjo, Sergio; Valente, Bruno; Lousinha, AnaIntroduction: In patients with atrial fibrillation (AF), up to one third have recurrence after a first catheter ablation (CA). Epicardial adipose tissue (EAT) has been considered to be closely related to AF, with a potential role in its recurrence. We aimed to evaluate the association between the volume of EAT measured by cardiac computed tomography (CT) and AF recurrence after CA. Methods: Consecutive AF patie...
Non-vitamin K oral anticoagulants assessment in high risk of bleeding patients ...
Silva Cunha, Pedro; Viveiros Monteiro, André; Coutinho Cruz, Madalena; Malveiro, Paula; Reis, João Pedro; Portugal, Guilherme; Dias, AnaAtrial fibrillation (AF) is commonly associated with advanced age and the presence of multiple, concomitant acute and chronic health conditions, placing this population at high risk for serious therapeutic side effects. Nonvitamin K antagonist oral anticoagulants (NOACs) are increasingly used for stroke prevention in patients with atrial fibrillation. The purpose of this study was to investigate the effectivene...
Lockdown measures for COVID-19 outbreak and variation in physical activity in p...
Silva Cunha, Pedro; Laranjo, Sérgio; Lourenço, André; Rodrigues, Lourenço; Cardoso, Isabel; Portugal, Guilherme; Valente, Bruno; Delgado, Ana SofiaAims: The present study analysed the patterns of physical activity pre-, during and post-lockdown measures for COVID-19 pandemic in patients with chronic heart failure (CHF) and cardiac implantable electronic devices (CIED) under remote monitoring (RM), and assessed the physical activity patterns during these periods. Methods: The raw data from 95 patients with CHF (age 67,7 +/- 15,1 years, 71,5% male) correspo...
Circulating miRNAs are associated with the systemic extent of atherosclerosis :...
Pereira da Silva, Tiago; Napoleão, Patricia; Costa, Marina C.; Gabriel, André F.; Selas, Mafalda; Silva, Filipa; Enguita, Francisco J.The mechanisms that regulate the systemic extent of atherosclerosis are not fully understood. We investigated whether the expression of circulating miRNAs is associated with the extent of stable atherosclerosis to a single territory or multiple territories (polyvascular) and with the severity of atherosclerosis in each territory. Ninety-four participants were prospectively recruited and divided into five age- a...
Soluble CD40 ligand expression in stable atherosclerosis: a systematic review a...
Pereira-da-Silva, Tiago; Ferreira, Vera; Castelo, Alexandra; Caldeira, Daniel; Napoleão, Patricia; Pinheiro, Teresa; Ferreira, Rui CruzBackground and aims: The role of inflammation in atherosclerosis development and expression in different arterial territories is unclear. Soluble CD40 ligand (sCD40L) mediates inflammation and atherogenesis. Through a systematic review and meta-analysis, we assessed whether sCD40L was dysregulated in stable atherosclerosis, irrespective of the diseased arterial territory, and whether this dysregulation differed...
Myocardial work is associated with significant left ventricular myocardial fibr...
Gonçalves, António Valentim; Rosa, Sílvia Aguiar; Branco, Luísa; Galrinho, Ana; Fiarresga, António; Lopes, Luis; Thomas, Boban; Baquero, LuísLate gadolinium enhancement on cardiac magnetic resonance adds prognostic information in patients with hypertrophic cardiomyopathy. Whether Myocardial work, a new parameter on transthoracic echocardiographic, can be associated with significant fibrosis in hypertrophic cardiomyopathy patients is unknown. In a single-centre prospective evaluation of hypertrophic cardiomyopathy patients in whom transthoracic echoc...