6 documents found, page 1 of 1
Highly potent anti-leishmanial derivatives of hederagenin, a triperpenoid from ...
Rodríguez-Hernández, Diego; Barbosa, Luiz C.A.; Demuner, Antonio J.; Almeida, Raquel M.de; Fujiwara, Ricardo T.; Ferreira, Sebastião R.Leishmaniasis is a neglected tropical disease (NTDs), endemic in 88 countries that affect more than 12 million people. Current drugs are limited due to their toxicity, development of biological resistance, length of treatment and high cost. Thus, the search for new effective and less toxic treatments is an urgent need. In this study, we report the synthesis of 3 new amide derivatives of hederagenin (22–24) with...
Predatory activity of the nematophagous fungus Duddingtonia flagrans on horse c...
Braga, Fabio R.; Araújo, Jackson V.; Silva, André. R.; Carvalho, Rogério O.; Araujo, Juliana M.; Ferreira, Sebastião R.; Benjamin, Laércio A.This work was performed to determine the predatory capacity in vitro of the nematophagous fungus Duddingtonia flagrans (isolate AC001) on cyathostomin infective larvae of horse (L3). The experimental assay was carried out on plates with 2% water-agar (2% WA). In the treated group, each plate contained 1.000 L3 and 1.000 conidia of the fungus. The control group without fungus only contained 1.000 L3 in the plate...
Ovicidal activity of seven Pochonia chlamydosporia fungal isolates on Ascaris s...
Ferreira, Sebastião R.; Araújo, Jackson V.; Braga, Fabio R.; Araujo, Juliana M.; Carvalho, Rogério O.; Silva, André R.; Frassy, Luiza N.The ovicidal effect of the nematophagous fungus Pochonia chlamydosporia on eggs of Ascaris suum was tested under laboratory conditions. A. suum eggs were plated on 2% water–agar with seven fungal isolates (Isol. 5, Isol. 31, Isol. 1, VC1, Isol. 12, Isol. 22 and VC4) and control without fungus. After 5, 7, 10, 14, 15 and 21 days of incubation, approximately 100 eggs were removed from the plates and classified ac...
Predatory activity of Pochonia chlamydosporia fungus on Toxocara (syn. Neoascar...
Braga, Fabio R.; Ferreira, Sebastião R.; Araújo, Jackson V.; Araujo, Juliana M.; Silva, André R.; Carvalho, Rogério O.; Campos, Artur K.Toxocara (Neoascaris) vitulorum is a gastrointestinal nematode parasite of young ruminants, responsible for high mortality rates in parasitized cattle and buffalo calves. The objective of this work was to compare the predatory capacity under laboratory conditions of four fungal isolates of the nematophagous fungus Pochonia chlamydosporia (VC1, VC4, VC5 and VC12) on T. vitulorum eggs in 2% water-agar (2% WA). T....
Leishmanicidal and cytotoxic activity of hederagenin-bistriazolyl derivatives
Rodríguez-Hernández, Diego; Barbosa, Luiz C.A.; Demuner, Antonio J.; Nain-Perez, Amalyn; Ferreira, Sebastião R.; Fujiwara, Ricardo T.Aiming to obtain new potent leishmanicidal and cytotoxic compounds from natural sources, the triterpene hederagenin was converted into several new 1,2,3-triazolyl derivatives tethered at C-23 and C-28. For this work hederagenin was isolated from fruits of Sapindus saponaria and reacted with propargyl bromide to afford as a major product bis-propargylic derivative 1 in 74%. Submitting this compound to Huisgen 1,...
Survival of Pochonia chlamydosporia in the gastrointestinal tract of experiment...
Araujo, Juliana M.; Araújo, Jackson V.; Braga, Fabio R.; Araújo, Dayane M.; Ferreira, Sebastião R.; Soares, Filippe E.F.; Benjamin, Laércio dos A.The predatory capacity of the nematophagous fungus Pochonia chlamydosporia (isolate VC4) after passage through the gastrointestinal tract of dogs was assessed in vivo against Toxocara canis eggs. Twelve dogs previously wormed were divided into two groups of six animals and caged. The treatments consisted of a fungus-treated group (VC4) and a control group without fungus. Each dog of the fungus-treated group rec...