41 documents found, page 1 of 5
Effects of oral supplementation of black-eyed-bean (Vigna unguiculata) in ICR m...
Ferreira, T; Silva-Reis, R; Mendes, BAL; Faustino-Rocha, AI; Carvalho, M; Castro I; Carnide, V; Coutinho, J; Gama, A; Rosa, E; Oliveira, PAGrain legumes are a main source of nutrients in some countries. Black-eyed-bean (BEB) (Vigna unguiculata), a member of theFabaceae family, is a grain legume consumed worldwide due to its high content of bioactive molecules that promote human health. This study aimed to evaluate the effects of 70% BEB flour (BEBF) (w/w) supplementation in ICR healthy mice for 13 weeks. Body and organs weights, as well as food an...
The role of natural compounds in rat mammary cancer: the beneficial effects of ...
Azevedo, Tiago; Silva, J; Faustino-Rocha, Ana I; Valada, A; Anjos, L; Moura, T; Ferreira, T; Santos, M; Pires, MJ; Neuparth, MJ; Peixoto, FBreast cancer is the most diagnosed cancer among women, and a leading cause of death worldwide. Santolina chamaecyparissus L. is a plant with multiple health benefits, includ- ing anticancer and anti-diabetic properties. This study aimed to assess the chemopreven- tive effects of S. chamaecyparissus aqueous ex- tract (SCE) in an animal model of mammary cancer. A total of 28 four-week-old female Wistar rats were...
Cytinus hypocistis (L.) L. extract effects in an animal model of papillomavirus...
Medeiros, C; Silva, AR; Ferreira, T; Barros, L; Neuparth, MJ; Peixoto, F; Bastos, MMSM; Medeiros, R; Gil da Costa, RM; Pires, MJ; Faustino-Rocha, Ana Infections with certain types of papillomavirus, such as the human papillomavirus 16 (HPV16), are associated with the development of preneoplastic lesions and cancers of the anogenital, and head and neck regions. Cytinus hypocistis (L.) L. extracts are composed of substances presenting antiproliferative, antioxidant, anti-inflammatory and antibacterial properties, which might be promising as new therapeutic comp...
Characterizing the molecular and physiological changes associated with colorect...
Silva-Reis, R; Faustino-Rocha, Ana I; Castro-Ribeiro, C; Gonçalves, M; Ferreira, T; Pires, MJ; Iglesias- Aguierre, CE; Cortés-Martín, A; Selma, MVCharacterizing the molecular and physiological changes associated with colorectal cancer in wistar rats
Natural products-based antiangiogenic agents: new frontiers in cancer therapy
Azevedo, T; Ferreira, T; Pena-Corona, SI; Cortes, H; Silva-Reis, R; Gil da Costa, RM; Faustino-Rocha, Ana I; Oliveira, PA; Calina, D; Cardoso, MAngiogenesis, vital for tumor growth and metastasis, is a promising target in cancer therapy. Natural compounds offer potential as antiangiogenic agents with reduced toxicity. This review provides a comprehensive overview of natural product-based antiangiogenic therapies, focusing on molecular mechanisms and therapeutic potential. A systematic search identified relevant articles from 2019 to 2023. Various natur...
Mammary glands of women, female dogs and female rats: similarities and differen...
Ferreira, T; Gama, A; Seixas, F; Faustino-Rocha, AI; Lopes, C; Gaspar, VM; Mano, J; Medeiros, R; Oliveira, PABreast cancer is one of the most common and well-known types of cancer among women worldwide and is the most frequent neoplasm in intact female dogs. Female dogs are considered attractive models or studying spontaneous breast cancer, whereas female rats are currently the most widely used animal models for breast cancer research in the laboratory context. Both female dogs and female rats have contributed to the ...
Invasive Bacterial Infections in Children With Sickle Cell Disease: 2014–2019
Gaschignard, J; Koehl, B; Rees, DC; Rincón-López, E; Vanderfaeillie, A; Pascault, A; Allali, S; Cela, E; Odièvre, MH; Hau, I; Oliveira, M; Guillaumat, CBackground: Children with sickle cell disease (SCD) are at a high risk of invasive bacterial infections (IBI). Universal penicillin prophylaxis and vaccination, especially against Streptococcus pneumoniae, have deeply changed its epidemiology. Analysis of IBI in children with SCD in a post-13-valent pneumococcal vaccine era is limited. Methods: Twenty-eight pediatric hospitals from 5 European countries retrospe...
Invasive and Subcutaneous Infections Caused by Filamentous Fungi: Report from a...
Veríssimo, C; Toscano, C; Ferreira, T; Abreu, G; Simões, H; Diogo, J; Carvalho, D; Santiago, F; Lima, A; Queirós, AM; Sabino, RInvasive fungal infections (IFI) have significantly increased over the past years due to advances in medical care for the at-risk immunocompromised population. IFI are often difficult to diagnose and manage, and can be associated with substantial morbidity and mortality. This study aims to contribute to understanding the etiology of invasive and subcutaneous fungal infections, their associated risk factors, and...
Disclosing Azole Resistance Mechanisms in Resistant Candida Glabrata Strains En...
Salazar, SB; Pinheiro, MJ; Sotti-Novais, D; Soares, AR; Lopes, MM; Ferreira, T; Rodrigues, V; Fernandes, F; Mira, NPThe pathogenic yeast Candida glabrata is intrinsically resilient to azoles and rapidly acquires resistance to these antifungals, in vitro and in vivo. In most cases azole-resistant C. glabrata clinical strains encode hyperactive CgPdr1 variants, however, resistant strains encoding wild-type CgPDR1 alleles have also been isolated, although remaining to be disclosed the underlying resistance mechanism. In this st...
An integrative approach to characterize the early phases of dimethylhydrazine-i...
Silva-Reis, Carla; Castro-Ribeiro, C; Gonçalves, M; Ferreira, T; Pires, MJ; Iglesias-Aguirre, CE; Cortés-Martín, A; Selma, MV; Espín, JCThis study aimed to characterize an animal model of colorectal cancer (CRC) in the early stages of disease development. Twenty-nine male Wistar rats were divided into two control groups (CTRL1 and CTRL2), receiving EDTA–saline injections and two induced groups (CRC1 and CRC2), receiving 1,2-dimethylhydrazine (DMH) injections for seven consecutive weeks. CRC1 and CTRL1 were euthanized at the 11th week, while CRC...