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Chronic thromboembolic pulmonary hypertension: a comprehensive review of pathog...

Cazeiro, Daniel; Azaredo Raposo, Miguel; Guimarães, Tatiana; Lousada, Nuno; Jenkins, David; Inácio, João R.; Moreira, Susana; Mineiro, Ana

Chronic thromboembolic pulmonary hypertension (CTEPH) is part of group 4 of the pulmonary hypertension (PH) classification and generally affects more than a third of patients referred to PH centers. It is a three-compartment disease involving proximal (lobar-to-segmental) and distal (subsegmental) pulmonary arteries that are obstructed by persistent fibrothrombotic material, and precapillary pulmonary arteries ...


Multidimensional CT approach to predict hemodynamics in pulmonary hypertension

Brito, Joana; Alves da Silva, Pedro; Cazeiro, Daniel; Azaredo Raposo, Miguel; Lousada, Nuno; Inácio, João R.; Guimarães, Tatiana; Almeida, Ana G.

Aim: Computed tomographic pulmonary angiography (CTPA) allows an excellent visualization of heart chambers and vessels, which may be associated with hemodynamic status in pulmonary hypertension, obviating the need for repetitive right heart catheterization (RHC). In this study, we aimed to evaluate the capacity of CTPA to predict severe hemodynamics and to correlate with clinical status and events. Material and...


Pulmonary arterial hypertension with features of venous involvement: a detectiv...

Cazeiro, Daniel; Plácido, Rui; Azaredo Raposo, Miguel; Brito, Joana; Borba, Alexandra; Guimarães, Tatiana; Pinto, Eugénia; Freitas, Pedro

Pulmonary veno-occlusive disease (PVOD) and pulmonary capillary hemangiomatosis are rare types of histopathological substrates within the spectrum of pulmonary arterial hypertension (PAH) with a very poor prognosis. They are characterized by a widespread fibroproliferative process of the small caliber veins and/or capillaries with sparing of the larger veins, resulting in a pre-capillary pulmonary hypertension ...


Chronic thromboembolic pulmonary hypertension: initial experience of patients u...

Plácido, Rui; Guimarães, Tatiana; Jenkins, David; Cortez-Dias, Nuno; Couto Pereira, Sara Cristina; Campos, Paula; Mineiro, Ana; Lousada, Nuno

Introduction and objectives: Pulmonary endarterectomy (PEA) is a potentially curative procedure in patients with chronic thromboembolic pulmonary hypertension (CTEPH). This study reports the initial experience of a Portuguese PH center with patients undergoing PEA at an international surgical reference center. Methods: Prospective observational study of consecutive CTEPH patients followed at a national PH cente...


More than a rare cause of pulmonary hypertension in the elderly

Plácido, Rui; Sousa, Isabel; Antunes, Dulce; Guimarães, Tatiana; Pinto, Fausto J.

An 80-year-old woman with a history of systemic hypertension and dual-chamber pacemaker implantation for sick sinus syndrome presented to the hospital with worsening dyspnea and fatigue for several months. The chest X-ray (Figure 1A) showed a markedly enlarged cardiac silhouette along with a tubular opacity (dotted lines) paralleling the right heart border. Echocardiographic examination depicted dilated right h...


The sensitivity of DPD scintigraphy to detect transthyretin cardiac amyloidosis...

Coutinho, Maria Conceição Azevedo; Cortez-Dias, Nuno; Cantinho, Guilhermina; Gonçalves, Susana; Menezes, Miguel Nobre; Guimarães, Tatiana

Background: There is a growing need for a non-invasive test to detect cardiac involvement in patients with transthyretin-related hereditary amyloidosis (ATTR) caused by V30M mutation. 99mTc-3,3-diphosphono-1,2-propanodicarboxylic acid (DPD) scintigraphy is a promising method, but its accuracy in this particular mutation remains unknown. Methods: A cohort of 179 patients: 92 with early-onset disease (EoD, sympto...


Non‐invasive telemonitoring improves outcomes in heart failure with reduced eje...

Nunes-Ferreira, Afonso; Agostinho, João R.; Rigueira, Joana; Aguiar-Ricardo, Inês; Guimarães, Tatiana; Santos, Rafael; Rodrigues, Tiago; Cunha, Nelson

Aims: Non-invasive telemonitoring (TM) in patients with heart failure (HF) and reduced left ventricular ejection fraction (HFrEF) may be useful in the early diagnosis of HF decompensation, allowing therapeutic optimization and avoiding re-hospitalization. We describe a TM programme in this population and evaluate its effectiveness during a 12 month period. Methods and results: We conducted a single-centre study...


Modified snare technique improves left ventricular lead implant success for car...

Marques, Pedro; Nunes-Ferreira, Afonso; António, Pedro S.; Aguiar-Ricardo, Inês; Lima da Silva, Gustavo; Guimarães, Tatiana; Bernardes, Ana

Background: Left ventricular (LV) lead placement is the most challenging aspect of cardiac resynchronization therapy (CRT) device implantation, with a failure rate of up to 10% due to complex coronary anatomies. We describe a modified snare technique for LV lead placement and evaluate its safety and efficacy in cases when standard methods fail. Methods and Results: A prospective study was conducted of patients ...


Congenital submitral diverticulum

Guimarães, Tatiana; Plácido, Rui; Almeida, Ana G.

A 36-year-old Guinean woman was referred to our center for a closer examination of systolic murmur. She had no cardiovascular complaints. Echocardiographic examinations depicted a large saccular structure at the left ventricular lateral and infer-lateral walls, in the submitral region (Figure 1). The outpouching structure was connected to the left ventricle (LV) through a large neck. In diastole, blood flowed f...


Heart disease and pregnancy : state of the art

Guimarães, Tatiana; Magalhaes, Andreia; Veiga, Arminda; Fiuza, Manuela; Ávila, Walkíria; Pinto, Fausto J.

The association between heart disease and pregnancy is increasingly prevalent. Although most women with heart disease tolerate the physiological changes of pregnancy, there are heart conditions that manifest for the first time during pregnancy and others that totally contraindicate a pregnancy. It is therefore important to establish multidisciplinary teams dedicated to the management of women with heart disease...


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