7 documents found, page 1 of 1

New Insights Into the Role of Tissue Eosinophils in the Progression of Colorect...

Introduction: Amongst the inflammatory cells implicated in the immune surveillance of colorectal cancer, a growing body of evidence suggests a role for eosinophils in carcinogenesis. We aimed to review the value of tumour-associated tissue eosinophilia (TATE) in the prognosis of colorectal cancer emphasizing the identification and measurement of tissue-infiltrating eosinophils and their association with the cli...

O Clínico e o Anatomopatologista

O sucesso das relações interpessoais, incluindo a relação entre clínicos e anatomopatologista, passa necessariamente por uma comunicação eficaz. Num momento em que várias Instituições Portuguesas de ensino em Medicina Veterinária passam, ou recentemente passaram, por processos de avaliação, relembra-se que a comunicação eficaz entre profissionais é recomendada como uma day-one skill pela European Association of...

An immunohistochemical study on the expression of sex steroid receptors, Ki-67 ...

TLR9 activation dampens the early inflammatory response to paracoccidioides bra...

Background: Paracoccidioides brasiliensis causes paracoccidioidomycosis, one of the most prevalent systemic mycosis in Latin America. Thus, understanding the characteristics of the protective immune response to P. brasiliensis is of interest, as it may reveal targets for disease control. The initiation of the immune response relies on the activation of pattern recognition receptors, among which are TLRs. Both T...

Mycobacterium tuberculosis strains are differentially recognized by TLRs with a...

Tuberculosis associates with a wide spectrum of disease outcomes. The Beijing (Bj) lineage of Mycobacterium tuberculosis (Mtb) is suggested to be more virulent than other Mtb lineages and prone to elicit non-protective immune responses. However, highly heterogeneous immune responses were reported upon infection of innate immune cells with Bj strains or stimulation with their glycolipids. Using both in vitro and...

Feline endometrial adenocarcinomas

Endometrial adenocarcinomas are considered to be rare in domestic animals, in particular comparing to non-epithelial tumours of the uterus such as leiomyoma, in part because they are likely underdiagnosed. In cats, though uterus was the most common site for genital tract tumours, endometrial adenocarcinomas were found to be rare in all available references. In the study presented herein, forty feline primary en...

TLR2 deficiency by compromising p19 (IL-23) expression limits T helper 17 cell ...

The authors are grateful to Drs. Manuel Teixeira da Silva, Fernando Rodrigues, Margarida Correia-Neves and Paul S. Redford for critically reading this manuscript and thank the personnel at the ICVS animal house facility for excellent animal husbandry.; CD4+ Th1 cells producing IFN-γ are of extreme importance in controlling infections by Mycobacterium tuberculosis both in mice and in men. In addition to IFN-γ-pr...