2 documents found, page 1 of 1
SLCO1B1 RS4149056 polymorphism associated with statin-induced myopathy is diffe...
Santos, Paulo Caleb Júnior de Lima; Soares, Renata A. G.; Nascimento Neto, Raimundo Marques do; Coelho, George Luiz Lins Machado; Mill, José GeraldoBackground: Recent studies reported the association between SLCO1B1 polymorphisms and the development of statin-induced myopathy. In the scenario of the Brazilian population, being one of the most heterogeneous in the world, the main aim here was to evaluate SLCO1B1 polymorphisms according to ethnic groups as an initial step for future pharmacogenetic studies. Methods: One hundred and eighty-two Amerindians plu...
CYP2C19 and ABCB1 gene polymorphisms are differently distributed according to e...
Santos, Paulo Caleb Júnior de Lima; Soares, Renata A. G.; Santos, Diogo B. G.; Nascimento Neto, Raimundo Marques do; Coelho, George Luiz Lins MachadoBackground: Recent studies have reported the clinical importance of CYP2C19 and ABCB1 polymorphisms in an individualized approach to clopidogrel treatment. The aims of this study were to evaluate the frequencies of CYP2C19 and ABCB1 polymorphisms and to identify the clopidogrel-predicted metabolic phenotypes according to ethnic groups in a sample of individuals representative of a highly admixtured population. ...