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Bronchodilator responsiveness and future chronic airflow obstruction

Funding Information: Acknowledgements: We thank all participants and staff for their time and effort put into this study. Infrastructure support for this research was provided by the NIHR Imperial Biomedical Research Centre (BRC). Funding Information: National Heart and Lung Institute, UK Medical Research Council, and Wellcome Trust.We thank all participants and staff for their time and effort put into this stu...

Quality of life associated with breathlessness in the multinational Burden of O...

Publisher Copyright: © 2025 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.; Introduction: Evidence of an association between breathlessness and quality of life from population-based studies is limited. We aimed to investigate the association of both physical and mental quality of life with breathlessness across several low-, middle- and high-income countries. Methods: We anal...

Geographical variation in lung function

Spirometry is used to determine what is "unusual" lung function compared with what is "usual" for healthy non-smokers. This study aimed to investigate regional variation in the forced vital capacity (FVC) and in the forced expiratory volume in one second to FVC ratio (FEV1/FVC) using cross-sectional data from all 41 sites of the multinational Burden of Obstructive Lung Disease study. Participants (5,368 men; 9,...

Prevalence of chronic cough, its risk factors and population attributable risk ...

BACKGROUND: Chronic cough is a common respiratory symptom with an impact on daily activities and quality of life. Global prevalence data are scarce and derive mainly from European and Asian countries and studies with outcomes other than chronic cough. In this study, we aimed to estimate the prevalence of chronic cough across a large number of study sites as well as to identify its main risk factors using a stan...

Prediction of severe exacerbations and mortality in COPD: the role of exacerbat...

Use of CPAP to reduce arterial stiffness in moderate-to-severe obstructive slee...

Introduction: Sleepiness is a cardinal symptom in obstructive sleep apnoea (OSA) but most patients have unspecific symptoms. Arterial stiffness, evaluated by pulse wave velocity (PWV), is related to atherosclerosis and cardiovascular (CV) risk. Arterial stiffness was reported to be higher in patients with OSA, improving after treatment with continuous positive airway pressure (CPAP). This study aims to assess w...