5 documents found, page 1 of 1
Neuroprotection and immunomodulation by dimethyl fumarate and a heterologous fi...
Kempe,Paula R. G.; Chiarotto,Gabriela Bortolança; Barraviera,Benedito; Ferreira Jr.,Rui Seabra; Oliveira,Alexandre L. R. deAbstract Background: Ventral root avulsion (VRA) is an experimental approach in which there is an abrupt separation of the motor roots from the surface of the spinal cord. As a result, most of the axotomized motoneurons degenerate by the second week after injury, and the significant loss of synapses and increased glial reaction triggers a chronic inflammatory state. Pharmacological treatment associated with roo...
Fibrin biopolymer as scaffold candidate to treat bone defects in rats
Cassaro,Claudia Vilalva; Justulin Jr.,Luis Antonio; Lima,Patrícia Rodrigues de; Golim,Marjorie de Assis; Biscola,Natália PerussiABSTRACT Background: Bone tissue repair remains a challenge in tissue engineering. Currently, new materials are being applied and often integrated with live cells and biological scaffolds. The fibrin biopolymer (FBP) proposed in this study has hemostatic, sealant, adhesive, scaffolding and drug-delivery properties. The regenerative potential of an association of FBP, biphasic calcium phosphate (BCP) and mesench...
BjussuLAAO-II induces cytotoxicity and alters DNA methylation of cell-cycle gen...
Machado,Ana Rita Thomazela; Aissa,Alexandre Ferro; Ribeiro,Diego Luis; Ferreira Jr.,Rui Seabra; Sampaio,Suely Vilela; Antunes,Lusânia Maria GreggiAbstract Background: The use of animal venoms and their toxins as material sources for biotechnological applications has received much attention from the pharmaceutical industry. L-amino acid oxidases from snake venoms (SV-LAAOs) have demonstrated innumerous biological effects and pharmacological potential against different cancer types. Hepatocellular carcinoma has increased worldwide, and the aberrant DNA met...
Traceability of animal protein byproducts in ruminants by multivariate analysis...
Ferreira Jr.,Rui Seabra; Silva,Daniela Alessandra Fossato da; Biscola,Natália Perussi; Sartori,Maria Márcia Pereira; Denadai,Juliana CéliaAbstract Background: Ruminant feed containing animal byproduct proteins (ABPs) is prohibited in many countries due to its risk of transmitting prion diseases (PD). In most cases the entire herd is sacrificed, which causes great harm to the producer countries by preventing their exportation of ruminant derived-products. Methods: We used stable isotope ratio mass spectrometry (IRMS) of carbon (13C/12C) and nitrog...
Multiple uses of fibrin sealant for nervous system treatment following injury a...
Biscola,Natalia Perussi; Cartarozzi,Luciana Politti; Ulian-Benitez,Suzana; Barbizan,Roberta; Castro,Mateus Vidigal; Spejo,Aline BarrosoAbstract Lesions to the nervous system often produce hemorrhage and tissue loss that are difficult, if not impossible, to repair. Therefore, scar formation, inflammation and cavitation take place, expanding the lesion epicenter. This significantly worsens the patient conditions and impairment, increasing neuronal loss and glial reaction, which in turn further decreases the chances of a positive outcome. The pos...