25 documents found, page 1 of 3
Inhibition of Myeloperoxidase Pro-Fibrotic Effect by Noscapine in Equine Endome...
Amaral, Ana; Cebola, Nélio; Szóstek-Mioduchowska, Anna; Rebordão, Maria Rosa; Kordowitzki, Paweł; Skarzynski, Dariusz; Ferreira-Dias, GraçaMyeloperoxidase is an enzyme released by neutrophils when neutrophil extracellular traps (NETs) are formed. Besides myeloperoxidase activity against pathogens, it was also linked to many diseases, including inflammatory and fibrotic ones. Endometrosis is a fibrotic disease of the mare endometrium, with a large impact on their fertility, where myeloperoxidase was shown to induce fibrosis. Noscapine is an alkaloi...
Inhibition of Myeloperoxidase Pro-Fibrotic Effect by Noscapine in Equine Endome...
Amaral, Ana; Cebola, Nélio; Szóstek-Mioduchowska, Anna; Rebordão, Maria Rosa; Kordowitzki, Paweł; Skarzynski, Dariusz; Ferreira-Dias, GraçaMyeloperoxidase is an enzyme released by neutrophils when neutrophil extracellular traps (NETs) are formed. Besides myeloperoxidase activity against pathogens, it was also linked to many diseases, including inflammatory and fibrotic ones. Endometrosis is a fibrotic disease of the mare endometrium, with a large impact on their fertility, where myeloperoxidase was shown to induce fibrosis. Noscapine is an alkaloi...
5-Aza-20 -Deoxycytidine (5-Aza-dC, Decitabine) Inhibits Collagen Type I and III...
Alpoim-Moreira, J.; Szóstek-Mioduchowska, A.; Słyszewska, M.; Rebordão, M.R.; Skarzynski, D.J.; Ferreira-Dias, GraçaEndometrosis negatively affects endometrial function and fertility in mares, due to excessive deposition of type I (COL1) and type III (COL3) collagens. The pro-fibrotic transforming growth factor (TGF-β1) induces myofibroblast differentiation, characterized by α-smooth muscle actin (α-SMA) expression, and collagen synthesis. In humans, fibrosis has been linked to epigenetic mechanisms. To the best of our knowl...
Inhibition of Myeloperoxidase Pro-Fibrotic Effect by Noscapine in Equine Endome...
Amaral, Ana; Cebola, Nélio; Zóstek-Mioduchowska, Anna; Rebordão, Maria Rosa; Kordowitzki, Paweł; Skarzynski, Dariusz; Ferreira-Dias, GraçaMyeloperoxidase is an enzyme released by neutrophils when neutrophil extracellular traps (NETs) are formed. Besides myeloperoxidase activity against pathogens, it was also linked to many diseases, including inflammatory and fibrotic ones. Endometrosis is a fibrotic disease of the mare endometrium, with a large impact on their fertility, where myeloperoxidase was shown to induce fibrosis. Noscapine is an alkaloi...
Metallopeptidades 2 and 9 genes epigenetically modulate equine endometrial fibr...
Alpoim-Moreira, Joana; Fernandes, Carina; Pimenta, J.; Bliebernicht, Miguel; Rebordão, Maria Rosa; Castelo-Branco, Pedro; Szostek-Mioduchowska, AnnaEndometrium type I (COL1) and III (COL3) collagen accumulation, periglandular fibrosis and mare infertility characterize endometrosis. Metalloproteinase-2 (MMP-2), MMP-9 and tissue inhibitors of metalloproteinases (TIMP-1 and TIMP-2) are involved in collagen turnover. Since epigenetic changes may control fibroproliferative diseases, we hypothesized that epigenetic mechanisms could modulate equine endometrosis. ...
Evolution of the concepts of endometrosis, post breeding endometritis, and susc...
Katila, Terttu; Ferreira-Dias, GraçaIn this paper, the evolution of our understanding about post breeding endometritis (PBE), the susceptibility of mares, and events leading to endometrosis are reviewed. When sperm arrive in the uterus, pro-inflammatory cytokines and chemokines are released. They attract neutrophils and induce modulatory cytokines which control inflammation. In susceptible mares, this physiological defense can be prolonged since ...
Metallopeptidades 2 and 9 genes epigenetically modulate equine endometrial fibr...
Alpoim-Moreira, Joana; Fernandes, Carina; Pimenta, Jorge; Bliebernicht, Miguel; Rebordão, Maria Rosa; Castelo-Branco, Pedro; Szóstek-Mioduchowska, AnnaEndometrium type I (COL1) and III (COL3) collagen accumulation, periglandular fibrosis and mare infertility characterize endometrosis. Metalloproteinase-2 (MMP-2), MMP-9 and tissue inhibitors of metalloproteinases (TIMP-1 and TIMP-2) are involved in collagen turnover. Since epigenetic changes may control fibroproliferative diseases, we hypothesized that epigenetic mechanisms could modulate equine endometrosis. ...
The effects of prostaglandin E-2 treatment on the secretory function of mare co...
Piotrowska-Tomala, Katarzyna K.; Jonczyk, Agnieszka W.; Szostek-Mioduchowska, Anna Z.; Zebrowska, Ewelina; Ferreira-Dias, Graça; Skarzynski, Dariusz J.We examined the effect of prostaglandin (PG) E2 on the secretory function of equine corpus luteum (CL), according to the application site: intra-CL injection vs. an intrauterine (intra-U) administration. Moreover, the effect of intra-CL injection vs. intra-U administration of both luteotropic factors: PGE2 and human chorionic gonadotropin (hCG) as a positive control, on CL function was additionally compared. Ma...
Collagen and microvascularization in placentas from young and older mares
Silva, Ana Catarina Neto; Costa, Ana Luísa; Teixeira, Ana; Alpoim-moreira, Joana; Fernandes, Carina; Fradinho, M.J.; Rebordão, Maria RosaIn older mares, increasing collagen fibers (fibrosis) in the endometrium and oviduct predisposes to sub-fertility and infertility. In this study, (i) gene transcription of collagen (qPCR: COL1A1, COL1A2, COL3A1, COL5A1); (ii) total collagen protein (hydroxyproline); (iii) collagen distribution (Picrosirius red staining; polarized light microscopy); and (iv) microvascular density (Periodic acid-Schiff staining),...
The NF-kappa B-signalling pathway in mare's endometrium infiltrated with the in...
Jasiński, Tomasz; Zdrojkowski, Łukasz; Kautz, Ewa; Juszczuk- Kubiak, Edyta; Ferreira-Dias, Graça; Domino, MałgorzataABSTRACT: Endometritis is an important issue decreasing mares' fertility. In the case of endo-metritis, both inflammatory cells infiltration and proinflammatory molecules produc-tion are regulated by various cellular and gene regulatory mechanisms, including the nuclear factor- κB (NF- κB)- dependent pathway. NF- κB- signalling pathway has been recently studied in the equine endometrium in the context of endome...