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Association between blood pressure and angiotensin-converting enzymes activity ...

Gaspar, AR; Andrade, B; Mosca, S; Ferreira-Duarte, M; Teixeira, A; Cosme, D; Albino-Teixeira, A; Ronchi, FA; Leite, AP; Casarini, DE; Areias, JC

Objectives:Angiotensin-converting enzymes' (ACEs) relationship with blood pressure (BP) during childhood has not been clearly established. We aimed to compare ACE and ACE2 activities between BMI groups in a sample of prepubertal children, and to characterize the association between these enzymes' activities and BP.Methods:Cross-sectional study of 313 children aged 8-9 years old, included in the birth cohort Gen...


Heterogeneity in protocols and outcomes to study the effect of renin-angiotensi...

Ferreira-Duarte, M; Tonin, FS; Duarte-Araujo, M; Fernandez-Llimos, F; Morato, M

Background: The renin-angiotensin system (RAS) has been associated with inflammatory bowel disease (IBD), supporting translational relevance of RAS blockers. Comparability of study design/outcomes is fundamental for data analysis/discussion. Objectives: We aimed at evaluating the heterogeneity among protocols and outcomes to study the effect of angiotensin-converting enzyme inhibitors or angiotensin receptor bl...


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