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Exposure to Obesogenic Environments during Perinatal Development Modulates Offs...
Sousa, Diana; Sá-Rocha, Mariana; Amaro, Andreia; Ferreira-Junior, Marcos Divino; Cavalcante, Keilah Valéria Naves; Monteiro-Alfredo, TamaehObesogenic environments such as Westernized diets, overnutrition, and exposure to glycation during gestation and lactation can alter peripheral neuroendocrine factors in offspring, predisposing for metabolic diseases in adulthood. Thus, we hypothesized that exposure to obesogenic environments during the perinatal period reprograms offspring energy balance mechanisms. Four rat obesogenic models were studied: mat...
Postnatal Overfeeding in Rodents Induces a Neurodevelopment Delay and Anxious-l...
Amaro, Andreia; Sousa, Diana Isabel Teixeira de; Sá-Rocha, Mariana; Ferreira-Junior, Marcos Divino; Rosendo-Silva, DanielaNutritional disturbances during the early postnatal period can have long-lasting effects on neurodevelopment and may be related to behavioural changes at adulthood. While such neuronal connection disruption can contribute to social and behaviour alterations, the dysregulation of the neuroendocrine pathways involved in nutrient-sensing balance may also cause such impairments, although the underlying mechanisms a...