6 documents found, page 1 of 1
Restoring neuropetide Y levels in the hypothalamus ameliorates premature aging ...
Ferreira-Marques, Marisa; Carmo Silva, Sara; Pereira, Joana; Botelho, Mariana; Nóbrega, Clévio; López‐Otín, Carlos; Almeida, Luís Pereira deThe hypothalamus has been recognized as a regulator of whole-body aging. Neuropeptide Y (NPY), highly abundant in the central nervous system and produced by the hypothalamus, enhances autophagy in this brain region and mediates autophagy triggered by caloric restriction, suggesting a potential role as a caloric restriction mimetic and an aging regulator. Considering that hypothalamic NPY levels decline during a...
Association between dietary intake and the expression of clock genes in adults:...
Lages, Marlene; Barros, Renata; Ferreira-Marques, Marisa; Correia, Joana; Caseiro, Armando; Guarino, Maria P.; Carmo Silva, SaraBackground: The circadian system regulates several physiological processes, including energy metabolism, through the expression of core clock genes. Animal studies suggest that dietary composition can influence circadian gene expression; however, evidence in humans remains limited. Objective: This study aimed to explore the association between dietary macronutrient intake and the expression of circadian clock g...
Association between dietary intake and the expression of clock genes in adults:...
Lages, Marlene; Correia, Joana; Caseiro, Armando; Carmo-Silva, Sara; Barros, Renata; Ferreira-Marques, Marisa; Guarino, Maria P.Background: The circadian system regulates several physiological processes, including energy metabolism, through the expression of core clock genes. Animal studies suggest that dietary composition can influence circadian gene expression; however, evidence in humans remains limited. Objective: This study aimed to explore the association between dietary macronutrient intake and the expression of circadian clock g...
Ghrelin delays premature aging in Hutchinson-Gilford progeria syndrome
Ferreira-Marques, Marisa; Carvalho, André; Franco, Ana Catarina; Leal, Ana; Botelho, Mariana; Carmo-Silva, Sara; Águas, Rodolfo; Cortes, LuísaHutchinson-Gilford progeria syndrome (HGPS) is a rare and fatal genetic condition that arises from a single nucleotide alteration in the LMNA gene, leading to the production of a defective lamin A protein known as progerin. The accumulation of progerin accelerates the onset of a dramatic premature aging phenotype in children with HGPS, characterized by low body weight, lipodystrophy, metabolic dysfunction, skin...
PI3K/AKT/MTOR and ERK1/2-MAPK signaling pathways are involved in autophagy stim...
Ferreira-Marques, Marisa; Carvalho, André; Cavadas, Cláudia; Aveleira, Célia A.Caloric restriction has been shown to robustly ameliorate age-related diseases and to prolong lifespan in several model organisms, and these beneficial effects are dependent on the stimulation of autophagy. Autophagy dysfunction contributes to the accumulation of altered macromolecules, and is a key mechanism of promoting aging and age-related disorders, as neurodegenerative ones. We have previously shown that ...
Caloric restriction stimulates autophagy in rat cortical neurons through neurop...
Ferreira-Marques, Marisa; Aveleira, Célia A.; Carmo-Silva, Sara; Botelho, Mariana; Pereira de Almeida, Luís; Cavadas, CláudiaCaloric restriction is an anti-aging intervention known to extend lifespan in several experimental models, at least in part, by stimulating autophagy. Caloric restriction increases neuropeptide Y (NPY) in the hypothalamus and plasma ghrelin, a peripheral gut hormone that acts in hypothalamus to modulate energy homeostasis. NPY and ghrelin have been shown to be neuroprotective in different brain areas and to ind...