3 documents found, page 1 of 1
Pharmacological NF-κB inhibition decreases cisplatin chemoresistance in muscle-...
Gil da Costa, Rui; Levesque, C; Bianchi-Frias D; Chatterjee, P; Lam, HM; Santos, C; Coleman, IM; Ferreirinha, P; Vilanova, M; Pinto da Cunha, NMost patients with muscle-invasive bladder cancer (MIBC) are not cured with platinum chemotherapy. Up-regulation of nuclear factor kappa light-chain enhancer of activated B cells (NF-κB) is a major mechanism underlying chemoresistance, suggesting that its pharmacological inhibition may increase platinum efficacy. NF-κB signaling was investigated in two patient cohorts. The Cancer Genome Atlas (TCGA) was used to...
Inhalation of Bacterial Cellulose Nanofibrils triggers an inflammatory response...
Silva-Carvalho, R; Silva, JP; Ferreirinha, P; Leitão, AF; Andrade, FK; Costa, RMG; Cristelo, C; Rosa, MF; Vilanova, M; Gama, FMIn view of the growing industrial use of Bacterial cellulose (BC), and taking into account that it might become airborne and be inhaled after industrial processing, assessing its potential pulmonary toxic effects assumes high relevance. In this work, the murine model was used to assess the effects of exposure to respirable BC nanofibrils (nBC), obtained by disintegration of BC produced by Komagataeibacter hanse...
Poly-N-acetylglucosamine production by Staphylococcus epidermidis cells increas...
Ferreirinha, P; Pérez-Cabezas, B; Correia, A; Miyazawa, B; França, A; Carvalhais, V; Faustino, A; Cordeiro-da-Silva, A; Teixeira, L; Pier, G; Cerca, NPoly-N-acetylglucosamine (PNAG) is a major component of the Staphylococcus epidermidis biofilm extracellular matrix. However, it is not yet clear how this polysaccharide impacts the host immune response and infection-associated pathology. Faster neutrophil recruitment and bacterial clearance were observed in mice challenged intraperitoneally with S. epidermidis biofilm cells of the PNAG-producing 9142 strain th...