4 documents found, page 1 of 1
Inhalation of bacterial cellulose nanofibrils triggers an inflammatory response...
Silva-Carvalho, Ricardo; Silva, João P.; Ferreirinha, Pedro; Leitão, A.; Andrade, Fábia K.; Costa, Rui M. Gil da; Cristelo, C.; Rosa, Morsyleide F.In view of the growing industrial use of Bacterial cellulose (BC), and taking into account that it might become airborne and be inhaled after industrial processing, assessing its potential pulmonary toxic effects assumes high relevance. In this work, the murine model was used to assess the effects of exposure to respirable BC nanofibrils (nBC), obtained by disintegration of BC produced by Komagataeibacter hanse...
Poly-N-acetylglucosamine production by Staphylococcus epidermidis cells increas...
Ferreirinha, Pedro; Pérez-Cabezas, B.; Correia, A.; Miyazawa, B.; França, Ângela Maria Oliveira Sousa; Carvalhais, Virgínia Maria Dinis; Faustino, A.Poly-N-acetyl glucosamine (PNAG) is a major component of Staphylococcus epidermidis biofilms extracellular matrix. However, it is not yet clear how this polysaccharide impacts the host immune response and infection-associated pathology. Faster neutrophil recruitment and bacterial clearance was observed in mice challenged intraperitoneally with S. epidermidis biofilm cells of the PNAG-producing 9142 strain than ...
Poly-N-acetyl glucosamine expression in Staphylococcus epidermidis biofilm cell...
Ferreirinha, Pedro; Pérez-Cabezas, Begoña; Correia, Alexandra; Miyazawa, Bruna; Carvalhais, Virgínia Maria Dinis; França, Ângela Maria Oliveira SousaStaphylococcus epidermidis is a biofilm - forming bacterium and a leading etiological agent of nosocomial infections. The ability to establish biofilms on indwelling medical devices is a key virulence factor for this bacterium. Still, the influence of poly - N - acetyl glucosamine (PNAG), the major component of the extracellular biofilm matrix, in the host immune response has been scarcely studied. Here, t h is...
Differential post-transcriptional regulation of IL-10 by TLR2 and TLR4-activate...
Rodrigues, Fernando; Pedrosa, Jorge; Coelho, Maria Teixeira; Guedes, Joana; Ferreirinha, Pedro; Howes, Ashleigh; Lai, Wi S.; Blackshear, Perry J.The activation of TLRs by microbial molecules triggers intracellular-signaling cascades and the expression of cytokines such as IL-10. Il10 expression is tightly controlled to ensure effective immune responses, while preventing pathology. Maximal TLR-induction of Il10 transcription in macrophages requires signaling through the MAPKs, ERK, and p38. Signals via p38 downstream of TLR4 activation also regulate IL-1...