3 documents found, page 1 of 1
Recent Advances in Extracellular Vesicles in Amyotrophic Lateral Sclerosis and ...
Afonso, Gonçalo; Cavaleiro, Carla; Valero, Jorge; Mota, Sandra; Ferreiro, E.Amyotrophic lateral sclerosis (ALS) is a severe and incurable neurodegenerative disease characterized by the progressive death of motor neurons, leading to paralysis and death. It is a rare disease characterized by high patient-to-patient heterogeneity, which makes its study arduous and complex. Extracellular vesicles (EVs) have emerged as important players in the development of ALS. Thus, ALS phenotype-express...
Tau-dependent suppression of adult neurogenesis in the stressed hippocampus
Dioli, Chrysoula; Patrício, P.; Trindade, R.; Pinto, L. G.; Silva, J. M.; Morais, M.; Ferreiro, E.; Borges, S.; Mateus-Pinheiro, A.; Rodrigues, A. J.Stress, a well-known sculptor of brain plasticity, is shown to suppress hippocampal neurogenesis in the adult brain; yet, the underlying cellular mechanisms are poorly investigated. Previous studies have shown that chronic stress triggers hyperphosphorylation and accumulation of the cytoskeletal protein Tau, a process that may impair the cytoskeleton-regulating role (s) of this protein with impact on neuronal f...
Mitochondrial- and endoplasmic reticulum-associated oxidative stress in Alzheim...
Ferreiro, E.; Baldeiras, I.; Ferreira, I. L.; Costa, R. O.; Rego, A. C.; Pereira, C. F.; Oliveira, C. R.Alzheimer's disease (AD) is the most common cause of dementia in the elderly, affecting several million of people worldwide. Pathological changes in the AD brain include the presence of amyloid plaques, neurofibrillary tangles, loss of neurons and synapses, and oxidative damage. These changes strongly associate with mitochondrial dysfunction and stress of the endoplasmic reticulum (ER). Mitochondrial dysfunctio...