6 documents found, page 1 of 1
Recent Advances of PDMS In Vitro Biomodels for Flow Visualizations and Measurem...
Souza, Andrews; Nobrega, Glauco Tapijara Vallicelli; Neves, Lucas Boniatti; Barbosa, Filipe; Ribeiro, J.E.; Ferrera, Conrado; Lima, Rui A.Polydimethylsiloxane (PDMS) has become a popular material in microfluidic and macroscale in vitro models due to its elastomeric properties and versatility. PDMS-based biomodels are widely used in blood flow studies, offering a platform for improving flow models and validating numerical simulations. This review highlights recent advances in bioflow studies conducted using both PDMS microfluidic devices and macro...
Experimental and numerical analyses of the hemodynamics impact on real intracra...
Souza, Andrews; Lopes, Diogo; Souza, Sérgio; Ribeiro, J.E.; Ferrera, Conrado; Lima, Rui A.This study investigates the impact of hemodynamics on real intracranial aneurysms (IAs) using experiments and computational fluid dynamics (CFD) simulations. A particle tracking velocimetry (PTV) approach was used to study the vortical structures inside a real aneurysm and validate numerical simulations performed at a steady regime for different flow rates. Moreover, this and two additional patient-specific cas...
Recent advances of PDMS in vitro biomodels for flow visualizations and measurem...
Souza, Andrews; Nobrega, Glauco; Neves, Lucas B.; Barbosa, Filipe; Ribeiro, João; Ferrera, Conrado; Lima, Rui Alberto Madeira MacedoPolydimethylsiloxane (PDMS) has become a popular material in microfluidic and macroscale in vitro models due to its elastomeric properties and versatility. PDMS-based biomodels are widely used in blood flow studies, offering a platform for improving flow models and validating numerical simulations. This review highlights recent advances in bioflow studies conducted using both PDMS microfluidic devices and macro...
Flow visualizations in a PDMS cerebral aneurysm biomodel
Souza, Andrews Victor Almeida; Ferrera, Conrado; Puga, Hélder; Lima, Rui A.; Ribeiro, J.E.; Souza, Maria SabrinaCerebral aneurysm is an abnormal dilatation of the blood vessel which affects a high percentage of the worldwide population. One way to investigate this pathology is using in vivo techniques, but these types of experiments have a high cost and low reproducibility. Thus, to understand the local hemodynamics of brain aneurysms, it is imperative to manufacture in vitro models that simulate real brain aneurysms. Th...
Additive manufacturing techniques for the fabrication of intracranial aneurysm ...
Rodrigues, D.; Souza, A.; Souza, Maria Sabrina; Ferrera, Conrado; Ribeiro, J.E.; Lima, Rui A.The hemodynamics of intracranial aneurysm (IA) involves complex phenomena that influence its growth and rupture. The advancement of additive manufacturing techniques allowed the development of biomodels suitable for in vitro experimental tests. Thus, we present in this work the process of manufacturing flow biomodels, using different additive manufacturing techniques and materials. The biomodels obtained throug...
3D manufacturing of intracranial aneurysm biomodels for flow visualizations: lo...
Souza, Andrews Victor Almeida; Souza, Mauren S.; Pinho, Diana; Agujetas, Rafael; Ferrera, Conrado; Lima, Rui A.; Puga, Hélder Fernandes; Ribeiro, J.E.There is a continuous search for better and more complete in vitro models with mechanical properties closer to in vivo conditions. In this work a manufacturing process, based on a lost core casting technique, is herein reported to produce aneurysm biomodels to perform experimental hemodynamic studies. By us- ing real artery images combined with a lost core casting technique, three materials were tested: paraffi...