Encontrados 11 documentos, a visualizar página 1 de 2
Motivos de exclusão para a cirurgia de estimulação cerebral profunda na doença ...
Carvalho, Miguel de Oliveira; Cattoni, Maria Begoña; Guedes, Leonor Correia; Carvalho, Herculano; Lobo, Patricia Pita; Albuquerque, Luisa
Dysphagia predicts poor outcome in late-stage Parkinson's disease
Fabbri, Margherita; Coelho, Miguel; Abreu, Daisy; Guedes, Leonor Correia; Rosa, Mario M.; Godinho, Catarina; Cardoso, Rita; Guimarães, Isabel"BACKGROUND: Few data exist on the rate of clinical progression for Parkinson's disease (PD) patients who have entered a late stage of the disease. OBJECTIVE: Study the clinical progression of a late-stage PD (LSPD) population over one year follow-up. METHODS: 50 LSPD patients (Schwab and England ADL Scale <50 or Hoehn Yahr Stage >3 in MED ON) underwent an extensive clinical assessment at baseline and after one...
Dysphagia predicts poor outcome in late-stage Parkinson's disease
Fabbri, Margherita; Coelho, Miguel; Abreu, Daisy; Guedes, Leonor Correia; Rosa, Mario M; Godinho, Catarina; Cardoso, Rita; Guimarães, Isabel
Speech and voice response to levodopa in late-stage Parkinson’s Disease patient...
Fabbri, Margherita; Guimarães, Isabel; Coelho, Miguel; Cardoso, R.; Guedes, Leonor Correia; Rosa, Mario M.; Godinho, Catarina; Antonini, Angelo
Neuromelanin magnetic resonance imaging of the Substantia Nigra in LRRK2-relate...
Guedes, Leonor Correia; Reimão, Sofia; Paulino, Patrícia; Nunes, Rita G.; Bouça-Machado, Raquel; Abreu, Daisy; Gonçalves, Nilza; Soares, Tiago
Response of non-motor symptoms to levodopa in late-stage Parkinson's disease: r...
Fabbri, Margherita; Coelho, Miguel; Guedes, Leonor Correia; Chendo, Inês; Sousa, Catarina; Rosa, Mario M.; Abreu, Daisy; Costa, Nilza; Godinho, Catarina"BACKGROUND: Non-motor symptoms (NMS) are extremely common among late-stage Parkinson's disease (LSPD) patients. Levodopa (L-dopa) responsiveness seems to decrease with disease progression but its effect on NMS in LSPD still needs to be investigated. OBJECTIVE: To assess the response of blood pressure (BP), pain, fatigue and anxiety to L-dopa in LSPD patients. METHODS: 20 LSPD patients, defined as Schwab and En...
Substantia nigra area evaluated by neuromelanin-sensitive MRI as an imaging bio...
Fabbri, Margherita; Reimão, Sofia; Carvalho, Miguel; Nunes, Rita G.; Abreu, Daisy; Guedes, Leonor Correia; Bouça, Raquel; Lobo, Patricia P.
Substantia nigra neuromelanin as an imaging biomarker of disease progression in...
Fabbri, Margherita; Reimão, Sofia; Carvalho, Miguel; Nunes, Rita G.; Abreu, Daisy; Guedes, Leonor Correia; Bouça, Raquel; Lobo, Patrícia P."BACKGROUND: A specific T1-weighted magnetic resonance imaging (MRI) sequence has been shown to detect substantia nigra (SN) neuromelanin (NM) signal changes that accurately discriminate Parkinson's disease (PD) patients from controls, even in early disease stages. However, it is unclear what happens to these SN changes in later disease stages and if they can be a marker of disease progression. OBJECTIVE: to in...
Speech and voice response to a Levodopa challenge in late-stage Parkinson’s Dis...
Fabbri, Margherita; Guimarães, Isabel; Cardoso, Rita; Coelho, Miguel; Guedes, Leonor Correia; Rosa, Maria M.; Godinho, Catarina; Abreu, Daisy"Background: Parkinson’s disease (PD) patients are affected by hypokinetic dysarthria, characterized by hypophonia and dysprosody, which worsens with disease progression. Levodopa’s (l-dopa) effect on quality of speech is inconclusive; no data are currently available for late-stage PD (LSPD). Objective: To assess the modifications of speech and voice in LSPD following an acute l-dopa challenge. Method: LSPD pat...
Speech and voice response to a Levodopa challenge in late-stage Parkinson’s dis...
Fabbri, Margherita; Guimarães, Isabel; Cardoso, Rita; Coelho, Miguel; Guedes, Leonor Correia; Rosa, Mário M; Godinho, Catarina; Abreu, DaisyBackground: Parkinson’s disease (PD) patients are affected by hypokinetic dysarthria, characterized by hypophonia and dysprosody, which worsens with disease progression. Levodopa’s (l-dopa) effect on quality of speech is inconclusive; no data are currently available for late-stage PD (LSPD). Objective: To assess the modifications of speech and voice in LSPD following an acute l-dopa challenge. Method: LSPD pati...