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The Complexities of Canine Monocytic Ehrlichiosis
Ferrolho, Joana; Antunes, Sandra; Vilhena, Hugo; Anastácio, Sofia; Ramalho de Sousa, Sérgio; Frouco, Gonçalo; Ferreira, Bárbara; Domingos, AnaFunding Information: This review was funded by the Portuguese Foundation for Science and Technology (FCT), projects UI/00772 and SFRH/122894/2016. Publisher Copyright: © 2025 by the authors.; Canine monocytic ehrlichiosis (CME) is a highly infectious disease with zoonotic potential. Ehrlichia canis, the causative agent, is primarily transmitted by Rhipicephalus sanguineus. Tick infestation and tick-borne diseas...
Quantitative proteomics identifies metabolic pathways affected by babesia infec...
Couto, Joana; Villar, Margarita; Mateos-Hernández, Lourdes; Ferrolho, Joana; Sanches, Gustavo S.; Santos, Ana Sofia; Santos-Silva, Maria MargaridaFunding Information: Funding: This research was funded by Fundação para a Ciência e Tecnologia (FCT) under the project TickOmic (PTDC/CVT-CVT/29073/2017). JC and JF are the recipients of Ph.D. grants supported by the FCT (SFRH/BD/121946/2016, SFRH/BD/122894/2016, respectively). Funding Information: Acknowledgments: A special thanks to Dr. Abel Oliva (Instituto de Tecnologia Química e Biológica, Universidade Nov...
Deciphering babesia-vector interactions
Antunes, Sandra; Rosa, Catarina; Couto, Joana; Ferrolho, Joana; Domingos, AnaUnderstanding host-pathogen-tick interactions remains a vitally important issue that might be better understood by basic research focused on each of the dyad interplays. Pathogens gain access to either the vector or host during tick feeding when ticks are confronted with strong hemostatic, inflammatory and immune responses. A prominent example of this is the Babesia spp.-tick-vertebrate host relationship. Babes...
Cattle Specific Immune Mechanisms used against the Protozoan Theileria annulata
Ferrolho, Joana; Domingos, A; Campino, LTheileria annulata, the causative agent of tropical theileriosis, is an intracellular protozoan parasite transmitted by ticks of the genus Hyalomma. This tick-borne disease (TBD) exerts a high impact on livestock production in many developing tropical and subtropical countries. With an intricate life cycle and wide distribution around the world, many advances were made to restrict the impact and to control this...
The role of regulatory CD4+CD25+ T cell subset in host homeostasis during proto...
Ferrolho, Joana; Domingues, Nuno; Domingos, A; Santos-Gomes, GHuman diseases caused by protozoan parasites are renowned for their high rates of morbidity and mortality worldwide. Some examples include African trypanosomiasis or sleeping sickness, American trypanosomiasis or Chagas disease, leishmaniases, malaria and babesiosis. These infections tend to follow a chronic rather than an acute course with lifelong persistence of parasites. Regulatory T cells (Treg), in partic...