5 documents found, page 1 of 1
Perinatal thymic-derived CD8αβ-expressing γδ T cells are innate IFN-γ producers...
Sumaria, Nital; Fiala, Gina; Inácio, Daniel; Curado Avelar, Marta Maria; Cachucho, Ana; Pinheiro, Rúben; Wiesheu, Robert; Kimura, ShunsukeThe contribution of γδ T cells to immune responses is associated with rapid secretion of interferon-γ (IFN-γ). Here, we show a perinatal thymic wave of innate IFN-γ-producing γδ T cells that express CD8αβ heterodimers and expand in preclinical models of infection and cancer. Optimal CD8αβ+ γδ T cell development is directed by low T cell receptor signaling and through provision of interleukin (IL)-4 and IL-7. Th...
Maternal γδ T cells shape offspring pulmonary type 2 immunity in a microbiota-d...
Papotto, Pedro H.; Yilmaz, Bahtiyar; Pimenta, Gonçalo; Mensurado, Sofia; Cunha, Carolina; Fiala, Gina; Gomes Da Costa, Daniel; Gonçalves-Sousa, NatachaImmune development is profoundly influenced by vertically transferred cues. However, little is known about how maternal innate-like lymphocytes regulate offspring immunity. Here, we show that mice born from γδ T cell-deficient (TCRδ-/-) dams display an increase in first-breath-induced inflammation, with a pulmonary milieu selectively enriched in type 2 cytokines and type 2-polarized immune cells, when compared ...
Distinct metabolic programs established in the thymus control effector function...
Lopes, Noel; McIntyre, Claire; Martin, Stefania; Raverdeau, Mathilde; Sumaria, Nital; Kohlgruber, Ayano C.; Fiala, Gina; Agudelo, Leandro Z.Metabolic programming controls immune cell lineages and functions, but little is known about γδ T cell metabolism. Here, we found that γδ T cell subsets making either interferon-γ (IFN-γ) or interleukin (IL)-17 have intrinsically distinct metabolic requirements. Whereas IFN-γ+ γδ T cells were almost exclusively dependent on glycolysis, IL-17+ γδ T cells strongly engaged oxidative metabolism, with increased mito...
From thymus to periphery : molecular basis of effector γδ‐T cell differentiation
Fiala, Gina; Gomes, Anita Q.; Silva-Santos, BrunoThe contributions of γδ T cells to immune (patho)physiology in many pre-clinical mouse models have been associated with their rapid and abundant provision of two critical cytokines, interferon-γ (IFN-γ) and interleukin-17A (IL-17). These are typically produced by distinct effector γδ T cell subsets that can be segregated on the basis of surface expression levels of receptors such as CD27, CD44 or CD45RB, among ...
How to develop IL-17-producing γδ T cells
Fiala, Gina; Silva-Santos, Brunoγδ T cells are an evolutionary conserved branch of the immune system and the first T cells to be generated in the developing mouse embryo. While αβ T cells are the predominant T cell subset in lymphoid organs, γδ T cells can constitute up to 50% of all T cells in tissues. Both αβ and γδ T cell subsets develop in the thymus, whereas αβ T cells egress as naïve cells that only aquire effector function upon activat...