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Third generation cephalosporin-resistant Klebsiella pneumoniae thriving in pati...
Rocha, Jaqueline; Ferreira, Catarina; Mil-Homens, Dalila; Busquets, Antonio; Fialho, Arsénio M.; Henriques, Isabel; Gomila, Margarita; Manaia, Célia M.Background Klebsiella pneumoniae are ubiquitous bacteria and recognized multidrug-resistant opportunistic pathogens that can be released into the environment, mainly through sewage, where they can survive even after wastewater treatment. A major question is if once released into wastewater, the selection of lineages missing clinically-relevant traits may occur. Wastewater (n = 25) and clinical (n = 34) 3(rd) ge...
Marine sponge and octocoral-associated bacteria show versatile secondary metabo...
Almeida, João F.; Marques, Matilde; Oliveira, Vanessa; Egas, Conceição; Mil-Homens, Dalila; Viana, Romeu; Cleary, Daniel F. R.; Huang, Yusheng M.Marine microbiomes are prolific sources of bioactive natural products of potential pharmaceutical value. This study inspected two culture collections comprising 919 host-associated marine bacteria belonging to 55 genera and several thus-far unclassified lineages to identify isolates with potentially rich secondary metabolism and antimicrobial activities. Seventy representative isolates had their genomes mined f...
Erratum for Oliveira et al., "K2 Capsule Depolymerase Is Highly Stable, Is Refr...
Oliveira, Hugo Alexandre Mendes; Mendes, Ana; Fraga, Alexandra G.; Ferreira, Alice Maria Fernandes; Pimenta, Andreia I.; Mil-Homens, DalilaVolume 85, no. 17, e00934-19, 2019, https://doi.org/10.1128/AEM.00934-19. Page 10, Acknowledgments, lines 4 and 5: POCI-01-0145-FEDER-016678 should read POCI-01-0145-FEDER-016643.
Novel capsular depolymerases-based strategy to kill multidrug-resistant pathoge...
Oliveira, Hugo Alexandre Mendes; Mendes, Ana; Fraga, Alexandra G.; Mil-Homens, Dalila; Fialho, Arsénio M.; Pedrosa, Jorge; Azeredo, JoanaMultidrug resistant pathogens represent one of the greatest threats to human health of the new millennium. ESKAPE bacterial pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa and other Enterobacteriaceae species) are the leading group among these socalled superbugs, which rapidly acquire resistances to several (and sometimes all) availa...
K2 capsule depolymerase is highly stable, is refractory to resistance, and prot...
Oliveira, Hugo Alexandre Mendes; Mendes, Ana; Fraga, Alexandra Gabriel; Ferreira, Alice Maria Fernandes; Pimenta, Andreia I.; Mil-Homens, DalilaAcinetobacter baumannii is emerging as a major nosocomial pathogen in intensive care units. The bacterial capsules are considered major virulence factors, and the particular A. baumannii capsular type K2 has been associated with high antibiotic resistance. In this study, we identified a K2 capsule-specific depolymerase in a bacteriophage tail spike C terminus, a fragment that was heterologously expressed, and i...
Modulation of membrane properties of lung cancer cells by azurin enhances the s...
Bernardes, Nuno; Abreu, Sofia; Carvalho, Filomena Almeida; Fernandes, Fábio; Santos, Nuno C.; Fialho, Arsénio M.In lung cancer, the Epidermal Growth Factor Receptor (EGFR) is one of the main targets for clinical management of this disease. The effectiveness of therapies toward this receptor has already been linked to the expression of integrin receptor subunit β1 in NSCLC A549 cells. In this work we demonstrate that azurin, an anticancer therapeutic protein originated from bacterial cells, controls the levels of integrin...
Erratum to: Cleanup of atrazine-contaminated soils: ecotoxicological study on t...
Chelinho, Sónia; Moreira-Santos, Matilde; Lima, Débora; Silva, Cátia; Viana, Paula; André, Sandra; Lopes, Isabel; Ribeiro, Rui; Fialho, Arsénio M.No abstract available.
Cleanup of atrazine-contaminated soils: ecotoxicological study on the efficacy ...
Chelinho, Sónia; Moreira-Santos, Matilde; Lima, Débora; Silva, Cátia; Viana, Paula; André, Sandra; Lopes, Isabel M.; Ribeiro, Rui; Fialho, Arsénio M.Purpose To mitigate the environmental effects of atrazine, one of the cleanup strategies available is based on the use of atrazine-degrading bacteria. This work aimed to evaluate the efficacy of a previously developed bioremediation tool for atrazine-contaminated soils (combining bioaugmentation with Pseudomonas sp. ADP, hereafter designated as P. ADP, and biostimulation with citrate) on both soil habitat and r...