6 documents found, page 1 of 1
Antimicrobial, antioxidant and other pharmacological activities of ocimum speci...
Javad Sharifi-Rad; Natália Cruz-Martins; E outros
Flavonoids as potential anti-platelet aggregation agents: from biochemistry to ...
Javad Sharifi-Rada; Cristina Quispe; Shabnum Shaheen; Mohammed El Haouari; Elena Azzini; Monica Butnariu; Natália Cruz-Martins; outros
Hesperetin's health potential: moving from preclinical to clinical evidence and...
Bahare Salehi; Natália Cruz-Martins; Monica Butnariu; Ioan Sarac; Iulia-Cristina Bagiu; Shahira M. Ezzat; Jinfan Wang; outros
Resistance profile of osimertinib in pre-treated patients with EGFR T790M-mutat...
Maria Gabriela O. Fernandes; Catarina Sousa; Maria Jacob; Leonor Almeida; Vanessa Santos; David Araújo; Hélder Novais Bastos; Adriana MagalhãesBackground: Osimertinib efficacy in pre-treated patients with epidermal growth factor receptor (EGFR) T790M-mutated non-small cell lung cancer (NSCLC) has been demonstrated in clinical trials, but real-world data, particularly regarding resistance profile, remains limited. This study aims to analyze the resistance mechanisms acquired after treatment with Osimertinib. Methods: Clinical outcomes and molecular res...
Clinical application of next-generation sequencing of plasma cell-free DNA for ...
Maria Gabriela O. Fernandes; Natália Cruz-Martins; Conceição Souto Moura; Susana Guimarães; Joana Pereira Reis; Ana Justino; Maria João PinaSimple Summary Plasma ctDNA is a material source for molecular analysis particularly useful when tissue is not available or sufficient. NGS-based plasma genotyping should be integrated into the clinical workup of newly diagnosed advanced NSCLC. Background: Analysis of circulating tumor DNA (ctDNA) has remarkable potential as a non-invasive lung cancer molecular diagnostic method. This prospective study addresse...
COVID-19 in relation to hyperglycemia and diabetes mellitus
Hayder M. Al-kuraishy; Ali I. Al-Gareeb; M. Alblihed; Susana Guerreiro; Natália Cruz-Martins; Gaber El-Saber BatihaCoronavirus disease 2019 (COVID-19), triggered by the severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2), may lead to extrapulmonary manifestations like diabetes mellitus (DM) and hyperglycemia, both predicting a poor prognosis and an increased risk of death. SARS-CoV-2 infects the pancreas through angiotensin-converting enzyme 2 (ACE2), where it is highly expressed compared to other organs, leading t...