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OPTImized Coronary Interventions EXplaIn the BEst CliNical OutcomEs (OPTI-XIENC...

Moreno, R; Bravo Baptista, S; Valencia, J; Gomez-Menchero, A; Bouisset, F; Ruiz-Arroyo, JR; Bento, A; Besutti, M; Jimenez-Valero, S; Rivero-Santana, B

Introduction: Clinical events may occur after percutaneous coronary intervention (PCI), particularly in complex lesions and complex patients. The optimization of PCI result, using pressure guidewire and intracoronary imaging techniques, may reduce the risk of these events. The hypothesis of the present study is that the clinical outcome of patients with indication of PCI and coronary stent implantation that are...


Microvascular Dysfunction Is Associated With Impaired Myocardial Work in Obstru...

Garcia Brás, P; Aguiar Rosa, S; Cardoso, I; Branco, L; Galrinho, A; Valentim Gonçalves, A; Thomas, B; Viegas, JM; Fiarresga, A; Branco, G; Pereira, R

Background Two-dimensional speckle tracking echocardiography has been shown to correlate with microvascular dysfunction, a hallmark of hypertrophic cardiomyopathy (HCM). We hypothesized that there is an association between myocardial work and left ventricular ischemia, with incremental value to global longitudinal strain, in patients with HCM. Methods and Results We performed a prospective assessment of patient...


Ventricular Septal Rupture—The Resurgence of a Post-Myocardial Infarction Dread...

Ferreira Reis, J; Almeida Morais, L; Sousa, L; Fiarresga, A

In the midst of the coronavirus disease-2019 (COVID-19) pandemic, an 84-year-old female patient was admitted due to non-exertional syncope preceded by retrosternal pain. She had experienced a prolonged episode of oppressive chest pain 6 days before her presentation, but due to the concern of contracting COVID-19, she did not present for medical care. Upon admission to the emergency department, the patient was i...


Late Gadolinium Enhancement in the Left Ventricular Wall Is Associated with Atr...

Castelo, A; Aguiar Rosa, S; Fiarresga, A; Jalles, N; Vaz Ferreira, V; Garcia Brás, P; Branco, L; Oliveira, M; Cruz Ferreira, R

Purpose: Atrial fibrillation (AF) is the most common arrhythmia in patients with hypertrophic cardiomyopathy (HCM). The aim of this study was to evaluate the relation between AF and left ventricular (LV) late gadolinium enhancement (LGE). Methods: 55 patients with HCM were retrospectively included. Patients were divided in HCM with AF and HCM without AF. Baseline clinical, echocardiographic and cardiovascular m...


Associations Between Perfusion Defects, Tissue Changes and Myocardial Deformati...

Brás, P; Aguiar Rosa, S; Thomas, B; Fiarresga, A; Cardoso, I; Pereira, R; Branco, G; Cruz, I; Baquero, L; Cruz Ferreira, R; Mota Carmo, M

Background: Microvascular dysfunction is an often overlooked feature of hypertrophic cardiomyopathy (HCM). Our aim was to assess the association between microvascular dysfunction, wall thickness, tissue characteristics and myocardial deformation in HCM patients, by analyzing individual myocardial segments. Methods: Prospective assessment including cardiac magnetic resonance to assess wall thickness, T1 and T2 m...



Index of Microcirculatory Resistance in the Assessment of Coronary Microvascula...

Aguiar Rosa, S; Mota Carmo, M; Rocha Lopes, L; Oliveira, E; Thomas, B; Baquero, L; Cruz Ferreira, R; Fiarresga, A

Introduction and objectives: Coronary microvascular dysfunction (CMD) is one of the most important pathophysiological features in hypertrophic cardiomyopathy (HCM). The index of microcirculatory resistance (IMR) is an invasive method to assess the coronary microcirculation. The aim was to assess CMD in patients with HCM by IMR. Methods: Adult patients with HCM without epicardial coronary artery disease underwen...


Blunted Coronary Flow Velocity Reserve is Associated With Impairment in Systoli...

Aguiar Rosa, S; Rocha Lopes, L; Branco, L; Galrinho, A; Fiarresga, A; Thomas, B; Brás, P; Gonçalves, A; Cardoso, I; Papoila, A; Alves, M; Rio, P

Background Coronary microvascular dysfunction constitutes an important pathophysiological feature in hypertrophic cardiomyopathy (HCM). We aimed to assess the association between impaired coronary flow velocity reserve (CFVR) and ventricular systolic function and functional capacity. Methods Eighty-three patients with HCM were enrolled in this prospective cohort study. Patients underwent echocardiogram to evalu...


Transcatheter Aortic Valve Implantation Outcomes in Patients with Low Flow Low ...

Castelo, A; Grazina, A; Mendonça, T; Rodrigues, I; Garcia Brás, P; Ferreira, V; Ramos, R; Fiarresga, A; Cacela, D; Cruz Ferreira, R

Background: Some studies suggest that patients with low flow low gradient (LF-LG) aortic stenosis (AS) may achieve worse results after undergoing transcatheter aortic valve implantation (TAVI). Purpose: To compare outcomes between LF-LG AS and high gradient (HG) AS patients submitted to TAVI. Methods: Inclusion of 480 consecutive patients who underwent TAVI between 2008 and 2020 at a single tertiary center. Pat...


Prevalence and Prognostic Impact of Apical Sparing Contractility Pattern in Pat...

Ferreira, V; Aguiar Rosa, S; Pereira-da-Silva, T; Rodrigues, I; Gonçalves, A; Mendonça, T; Castelo, A; Branco, LM; Galrinho, A; Fiarresga, A; Ramos, R

Introduction: Prolonged afterload increase in aortic stenosis (AS) may alter left ventricular (LV) contractility, irrespective of LV ejection fraction (LVEF). The prevalence and morbimortality associated with the apical sparing strain pattern (ASP), a typical finding of cardiac amyloidosis (CA), are not fully understood in patients with AS. We assessed the prevalence of the ASP in patients with severe AS and it...


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