9 documents found, page 1 of 1
Gene expression evaluation of antioxidant enzymes in patients with hepatocellul...
Alves,Andressa de Freitas; Moura,Ana Carolina de; Andreolla,Huander Felipe; Veiga,Ana Beatriz Gorini da; Fiegenbaum,Marilu; Giovenardi,MárciaAbstract Any condition leading to chronic liver disease is a potential oncogenic agent for hepatocellular carcinoma (HCC). Alterations in the expression of antioxidant enzymes could alter the redox balance. Our aim was to evaluate the expression of the genes GPX1, GPX4, SEP15, SELENOP, SOD1, SOD2, GSR, CAT, and NFE2L2 in patients with HCC. Differential gene expression analysis was performed using RNA-Seq data f...
Blood groups in Native Americans: a look beyond ABO and Rh
Rodrigues,Mirelen Moura de Oliveira; Höher,Gabriela; Waskow,Gabriela; Hutz,Mara Helena; Lindenau,Juliana Dal-Ri; Petzl-Erler,Maria LuizaAbstract The study presents comparisons between blood group frequencies beyond ABO and Rh blood systems in Native American populations and previously published data from Brazilian blood donors. The frequencies of Diego (c.2561C>T, rs2285644), Kell (c.578C>T, rs8176058), Duffy (c.125A>G, rs12075, c.1−67T>C, rs2814778) and Kidd (c.838A>G, rs1058396) variants in Kaingang (n=72) and Guarani (n=234) populations from...
Genetic variability of blood groups in southern Brazil
Waskow,Gabriela; Rodrigues,Mirelen Moura de Oliveira; Höher,Gabriela; Onsten,Tor; Lindenau,Juliana Dal-Ri; Fiegenbaum,Marilu; Almeida,SilvanaAbstract We evaluated genetic variability among the blood groups Kell (c.578C > T and c.1790T > C), Kidd (c.838A > G), Duffy (c.125A > G, c.265C > T and c.1-67T > C), Diego (c.2561C > T), MNS (c.143T > C) and Rh (c.676G > C) in Rio Grande do Sul in southern Brazil. Genetic profiling from 382 volunteer blood donors was performed through allelic discrimination assays using a hydrolysis probe (TaqMan®) with a real...
Depression and Memory Decline in the Elderly
Machado,Andréa Guedes; Dornelles,Paola Andressa de Lima; Andrade,Fabiana Michelsen de; Fiegenbaum,Marilu; Pádua,Analuiza Camozzato deAbstract Objective: To analyze the memory performance of participants aged 60 years and older with and without depressive symptoms. Methods: 199 participants were assessed using the Beck Depressio. In ventory (BDI) with a cut-off point of 20 for depression. Of these, 22 met the criteria for depression group; the remaining participants were allocated to the non-depression group. The Rey Auditory-Verbal Learning ...
Evaluation of Sexual Dimorphism in the Efficacy and Safety of Simvastatin/Atorv...
Smiderle,Lisiane; Lima,Luciana O.; Hutz,Mara Helena; Sand,Cézar Roberto Van der; Van der Sand,Luiz Carlos; Ferreira,Maria Elvira WagnerBackground: Dyslipidemia is the primary risk factor for cardiovascular disease, and statins have been effective in controlling lipid levels. Sex differences in the pharmacokinetics and pharmacodynamics of statins contribute to interindividual variations in drug efficacy and toxicity. Objective: To evaluate the presence of sexual dimorphism in the efficacy and safety of simvastatin/atorvastatin treatment. Method...
The lactase persistence genotype is a protective factor for the metabolic syndrome
Friedrich,Deise C.; Andrade,Fabiana M de; Fiegenbaum,Marilu; Almeida,Silvana de; Mattevi,Vanessa S.; Callegari-Jacques,Sidia M.; Hutz,Mara H.The Metabolic Syndrome (MetS) is defined as a pattern of metabolic disturbances, which include central obesity, insulin resistance and hyperglycemia, dyslipidemia, and hypertension. Milk has been promoted as a healthy beverage that can improve the management of MetS. Most human adults, however, down-regulate the production of intestinal lactase after weaning. Lactase encoded by the LCT gene is necessary for lac...
Incontinentia pigmenti
Poziomczyk,Claudia Schermann; Recuero,Julia Kanaan; Bringhenti,Luana; Maria,Fernanda Diffini Santa; Campos,Carolina Wiltgen; Travi,Giovanni MarcosIncontinentia pigmenti is a rare genodermatosis in which the skin involvement occurs in all patients. Additionally, other ectodermal tissues may be affected, such as the central nervous system, eyes, hair, nails and teeth. The disease has a X-linked dominant inheritance pattern and is usually lethal to male fetuses. The dermatological findings occur in four successive phases, following the lines of Blaschko: Fi...
Influência de combinações genéticas nos níveis de HDL-c em uma população do sul...
Andrade,Fabiana Michelsen de; Fiegenbaum,Marilu; Almeida,Silvana de; Hutz,Mara HelenaFUNDAMENTO: Baixos níveis de HDL-c são importantes preditores de doença coronariana, a primeira causa de morte no mundo todo. Muitos fatores afetam os níveis de HDL-c, tais como os polimorfismos de genes que codificam proteínas-chave para a via de transporte reverso de colesterol. OBJETIVO: Investigar a influência de sete polimorfismos dos genes CETP, APOA1, ABCA1 e SCARB1 genes nos níveis de HDL-c em uma popul...
Metabolic changes associated with antiretroviral therapy in HIV-positive patients
Almeida,Sabrina Esteves de Matos; Borges,Michele; Fiegenbaum,Marilu; Nunes,Cynara Carvalho; Rossetti,Maria Lucia RosaOBJECTIVE: To evaluate metabolic changes associated with highly active antiretroviral therapy (HAART) in HIV-positive patients, and to identify risk factors associated. METHODS: Retrospective study that included 110 HIV-positive patients who where on HAART in the city of Porto Alegre (Southern Brazil) between January 2003 and March 2004. Data on demographic variables, cigarette smoking, diabetes mellitus, chole...