3 documents found, page 1 of 1
A review on lactoferrin as a proton pump inhibitor
Pereira, Cátia Sofia Santos; Andrés, María T.; Fierro, José F.; Rodrigues, L. R.; Côrte-Real, ManuelaLactoferrin (Lf) is a versatile natural milk-derived protein that exhibits multiple interesting biological activities. Since it is safe for human administration and currently manufactured using low cost and well-established large-scale processes, the Lf scientific community has been devoted at dissecting its mechanisms of action towards its more rational and efficient use for various applications. Emerging lite...
Lactoferrin perturbs lipid rafts and requires integrity of Pma1p-lipid rafts as...
Pereira, Cátia Sofia Santos; Andrés, María T.; Chaves, Susana Alexandra Rodrigues; Fierro, José F.; Gerós, H.; Manon, Stéphen; Rodrigues, L. R.Lactoferrin (Lf) is a bioactive milk-derived protein with remarkable wide-spectrum antifungal activity. To deepen our understanding of the molecular mechanisms underlying Lf cytotoxicity, the role of plasma membrane ergosterol- and sphingolipid-rich lipid rafts and their association with the proton pump Pma1p was explored. Pma1p was previously identified as a Lf-binding protein. Results showed that bovine Lf (b...
Deciphering the mechanisms underlying bovine milk lactoferrin anticancer activi...
Pereira, Cátia Sofia Santos; Guedes, Joana P.; Chaves, Susana Alexandra Rodrigues; Andrés, María T.; Fierro, José F.; Gerós, H.; Rodrigues, L. R.Lactoferrin (Lf) is a milk derived iron-binding protein that exhibits a broad range of interesting biological activities, from which its anticancer and antifungal activities stand out. Our group has been elucidating the mechanisms and identifying the molecular targets underlying Lf anticancer/antifungal activities in order to improve its therapeutic efficacy and rational application. Indeed, we previously demon...