Encontrados 33 documentos, a visualizar página 1 de 4
Retrospective detection and genetic characterization of Porcine circovirus 3 (p...
Saraiva, Giuliana Loreto; Vidigal, Pedro Marcus Pereira; Assao, Viviane Sisdelli; Fajardo, Murilo Leone Miranda; Loreto, Alerrandra Nunes SaraivaPorcine circovirus 3 (PCV3) is an emerging virus that was first identified in the United States in 2016. Since its first detection, PCV3 has already been found in America, Asia, and Europe. Although PCV3 has already been described in Brazil, knowledge of its detection and sequence variation before 2016 is limited, as well as its distribution in the main swine producing regions of Brazil. In this study, 67 porci...
Evaluation of the antiviral activities of Bacharis dracunculifolia and querceti...
Ferreira, Caroline Gracielle Torres; Campos, Mateus Gandra; Felix, Daniele Mendes; Santos, Marcus Rebouças; Carvalho, Otávio Valério deEquid herpesvirus 1 (EHV-1) is a pathogen of high economic importance in equine breeding operations around the world. EHV-1 infection causes respiratory, neurologic and reproductive disease. The absence of an efficient therapy has caught the attention of the scientific community and the therapeutic activities of natural products with its antivirals effects might be effective for the disease's treatment. Herein ...
Synthesis and antimetastatic activity evaluation of cinnamic acid derivatives c...
Lima, Graziela Domingues de Almeida; Rodrigues, Michelle Peixoto; Moreira, Gabriela Alves; Mendes, Tiago Antônio de Oliveira; Siqueira, Raoni PaisIt is herein described the preparation and evaluation of antimetastatic activity of twenty-six cinnamic acid derivatives containing 1,2,3-triazolic portions. The compounds were prepared using as the key step the Copper(I)-catalyzed azide (A)-alkyne (A) cycloaddition (C) (CuAAC reaction), also known as click reaction, between alkynylated cinnamic acid derivatives and different benzyl azides. The reactions were c...
Antimetastatic effect of the pharmacological inhibition of serine/arginine-rich...
Moreira, Gabriela Alves; Lima, Graziela Domingues de Almeida; Siqueira, Raoni Pais; Barros, Marcus Vinícius de AndradeThe Serine/arginine-rich protein kinases (SRPK) are involved in pre-mRNA splicing control through the phosphorylation of the SR protein family of splicing factors. Over the last years, several studies have shown the relevance of SRPK for human cancers and their potential as promising drug targets. In this context, we have previously selected three trifluoromethyl arylamides (named here as SRVIC24, SRVIC30 and S...
Extracellular nucleotide metabolism in Leishmania: influence of adenosine in th...
Fietto, Juliana Lopes Rangel; Marques-da-Silva, Eduardo de Almeida; Oliveira, Jamile Camargos de; Figueiredo, Amanda Braga; Lima Júnior, Djalma de SouzaLeishmaniasis is a parasitic disease with a variety of clinical forms, which are related to the Leishmania species involved. In the murine model, Leishmania amazonensis causes chronic non-healing lesions in Leishmania braziliensis- or Leishmania major-resistant mouse strains. In this study, we investigated the involvement of the pathway of extracellular nucleotide hydrolysis, with special focus on the role of e...
E-NTPDase (ecto-nucleoside triphosphate diphosphohydrolase) of Leishmania amazo...
Souza Vasconcellos, Raphael de; Gomes, Rodrigo Saar; Carvalho, Luana Cristina Faria de; Fietto, Juliana Lopes Rangel; Afonso, Luís Carlos CroccoLeishmania amazonensis, the causal agent of diffuse cutaneous leishmaniasis, is known for its ability to modulate the host immune response. Because a relationship between ectonucleotidase activity and the ability of Leishmania to generate injury in C57BL/6 mice has been demonstrated, in this study we evaluated the involvement of ecto-nucleoside triphosphate diphosphohydrolase (E-NTPDase) activity of L. amazonen...
Trifluoromethyl arylamides with antileukemia effect and intracellular inhibitor...
Siqueira, Raoni Pais; Barros, Marcus Vinícius de Andrade; Barbosa, Éverton de Almeida Alves; Onofre, Thiago Souza; Gonçalves, Victor Hugo SousaThe serine/arginine-rich protein kinases (SRPKs) have frequently been found with altered activity in a number of cancers, suggesting they could serve as potential therapeutic targets in oncology. Here we describe the synthesis of a series of twenty-two trifluoromethyl arylamides based on the known SRPKs inhibitor N-(2-(piperidin-1-yl)-5-(trifluoromethyl)phenyl)isonicotinamide (SRPIN340) and the evaluation of th...
Distribution of infectious bronchitis virus strains in different organs and evi...
Pereira, Claiton Gonçalves; Saraiva, Giuliana Loreto; Vidigal, Pedro Marcus Pereira; Fietto, Juliana Lopes Rangel; Bressan, Gustavo CostaOn the basis of partial sequencing of the infectious bronchitis virus (IBV) S1 gene, this study investigated the molecular diversity of the virus in two life periods of a batch of breeding hens at the field level. The chicks were vaccinated against IBV on the second day of life with the vaccine Ma5, but at the age of 18 days, they exhibited clinical signs and macroscopic lesions compatible with avian infectious...
Label-free assay based on immobilized capillary enzyme reactor of Leishmania in...
Vasconcellos, Raphael de Souza; Magalhães, Luana; Oliveira, Arthur Henrique Cavalcante de; Mariotini-Moura, Christiane; Firmino, Rafaela de CássiaNucleoside triphosphate diphosphohydrolase (NTPDase) is an enzyme belonging to the apyrase family that participates in the hydrolysis of the nucleosides di- and triphosphate to the corresponding nucleoside monophosphate. This enzyme underlies the virulence of parasites such as Leishmania. Recently, an NTPDase from Leishmania infantum (LicNTPDase-2) was cloned and expressed and has been considered as a new drug ...
Evolutionary analysis of porcine circovirus 3 (PCV3) indicates an ancient origi...
Saraiva, Giuliana Loreto; Vidigal, Pedro Marcus Pereira; Fietto, Juliana Lopes Rangel; Bressan, Gustavo Costa; Silva Júnior, AbelardoPorcine circovirus 3 (PCV3) is an emerging virus that was identified in the United States in 2016. Since its first identification, PCV3 has been identified in Brazil, China, United States, Poland, and Republic of Korea. In this study, we used molecular phylogenetic analysis of available sequences to address questions surrounding the emergence of PCV3 in porcine world industry. Our data indicate that PCV3 did no...