3 documents found, page 1 of 1
Deciphering respiratory viral infections by harnessing organ-on-chip technology...
Koceva, Hristina; Amiratashani, Mona; Akbarimoghaddam, Parastoo; Hoffmann, Bianca; Zhurgenbayeva, Gaukhar; Gresnigt, Mark S.The lung microbiome has recently gained attention for potentially affecting respiratory viral infections, including influenza A virus, respiratory syncytial virus (RSV) and SARS-CoV-2. We will discuss the complexities of the lung microenvironment in the context of viral infections and the use of organ-on-chip (OoC) models in replicating the respiratory tract milieu to aid in understanding the role of temporary ...
Aspergillus fumigatus hijacks human p11 to redirect fungal-containing phagosome...
Jia, Lei-Jie; Rafiq, Muhammad; Radosa, Lukáš; Hortschansky, Peter; Cunha, Cristina; Cseresnyés, Zoltán; Krüger, Thomas; Schmidt, FranziskaThe decision whether endosomes enter the degradative or recycling pathway in mammalian cells is of fundamental importance for pathogen killing, and its malfunctioning has pathological consequences. We discovered that human p11 is a critical factor for this decision. The HscA protein present on the conidial surface of the human-pathogenic fungus Aspergillus fumigatus anchors p11 on conidia-containing phagosomes ...
Flotillin-dependent membrane microdomains are required for functional phagolyso...
Schmidt, Franziska; Thywißen, Andreas; Goldmann, Marie; Cunha, Cristina; Cseresnyés, Zoltán; Schmidt, Hella; Rafiq, Muhammad; Galiani, SilviaLipid rafts form signaling platforms on biological membranes with incompletely characterized role in immune response to infection. Here we report that lipid-raft microdomains are essential components of phagolysosomal membranes of macrophages and depend on flotillins. Genetic deletion of flotillins demonstrates that the assembly of both major defense complexes vATPase and NADPH oxidase requires membrane microdo...